| 摘要 |
探索高血压共病抑郁的危险因素，以便临床能够早期识别及提供早期干预。方法 纳入2017年6月-2022年5月在我院住院的高血压病患者，按照是否共病抑郁情绪，分为单纯高血压组（单纯组）及高血压共病抑郁组（共病组），探索2组患者人口学及血液指标〔总胆固醇(Total cholesterol,TC)、甘油三脂(triglycerides,TG)〕、超敏C反应蛋白（Hypersensitive C-reactive protein,Hs-CRP）及社会支持量表（Perceived Social Support Scale,PSSS）、心理弹性量表（the Connor-David son Resilience Scale,CD-RISC)）的差异性。使用非条件Logistic回归分析探索高血压共病抑郁的危险因素。结果 2组间存在在吸烟史、抑郁症家族史、TC、Hs-CRP、社会支持水平、心理弹性水平差异显著（P＜0.05）；非条件logistic回归示吸烟史(OR=2.375,P=0.024)、抑郁症家族史(OR=5.202,P＜0.001)、TC(OR=1.080,P＜0.001)、Hs-CRP(OR=2.635,P＜0.001)、社会支持水平(OR=1.873,P＜0.001)、心理弹性水平(OR=1.945,P＜0.001)与高血压共病抑郁密切相关。结论 有吸烟史、抑郁症家族史、高TC、高Hs-CRP、社会支持水平差、心理弹性水平低是高血压共病抑郁的危险因素。期待罹患高血压的个体积极遵从心脏康复遗嘱，从“双心”视角去减少共病状态。
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| Abstract |
Objective To explore risk factors for hypertensive comorbid depression,so that to enable clinical early identification and provide early intervention．Methods Hypertensive patients admitted to our hospital from June 2017 to May 2022 were included,according to whether the comorbid depression mood, divide to simple hypertension group (pure group) and hypertension comorbid depression group(comorbid group).Differences between the two groups were compared by the Total cholesterol（TC）,triglycerides（TG),Hypersensitive C-reactive protein（Hs-CRP) and the Perceived Social Support Scale（PSSS)and the Connor-Davidson Resilience Scale（CD-RISC).Risk factors for hypertensive comorbid depression were explored using unconditioned Logistic regression analysis.Results There were significant differences in smoking history,family history of depression,TC,Hs-CRP,social support level,and psychological resilience level(P<0.05);Nonconditional logistic regression showed the smoking history (OR=2.375),family history of depression(OR=5.202),TC(OR=1.080), Hs-CRP(OR=2.635),social support level(OR=1.873), psychological resilience level(OR=1.945)was strongly associated with hypertensive comorbid depression.Conclusion A history of smoking,family history of depression,high TC,high Hs-CRP,poor social support,and low psychological resilience are risk factors for hypertensive comorbid depression. Individuals with hypertension are expected to actively follow their cardiac rehabilitation will to reduce comorbidity from a "two-heart" perspective.
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