蓝萼乙素药理作用及其分子机制研究进展-现代生命科学研究-CSCIED科技核心评价数据库-手机版

蓝萼乙素药理作用及其分子机制研究进展

Progress in pharmacological activity and molecular mechanism of Glaucocalyxin B

ES评分 0 浏览量：902 下载量：0

DOI	10.12208/j.jlsr.20230001
刊名	现代生命科学研究 Journal of Modern Life Sciences Research
年，卷(期)	2023, 4(1)
作者	王明鑫智,王镜超,权泉,金成浩*,
作者单位	黑龙江八一农垦大学生命科学技术学院黑龙江大庆 ;
摘要	蓝萼乙素是从中草药香茶菜中分离出来的对映-贝壳杉烷型二萜。研究表明，蓝萼乙素不仅具有抗帕金森、防止神经元损伤、抗神经炎、抗类风湿关节炎等多种药理作用，还具有良好的抗肿瘤活性，尤其对宫颈癌、胃癌及乳腺癌具有明显的治疗效果。本文对近年来蓝萼乙素的药理作用及其分子机制的相关研究进展进行综述，为蓝萼乙素的开发和临床应用提供理论依据。
Abstract	Glaucocalyxin B is an enantio-kaurane diterpene isolated from the Chinese herbal medicine Camellia fragrans. Studies have shown that glaucocalyxin B not only has a variety of pharmacological effects such as anti-Parkinsons disease, prevention of neuronal damage, anti-neuritis, anti-rheumatoid arthritis, but also has good anti-tumor activity, especially for cervical cancer, gastric cancer and breast cancer. In this review, the pharmacological effects and molecular mechanisms of glaucocalyxin B were summarized in order to provide theoretical basis for the development and clinical application of glaucocalyxin B.
关键词	蓝萼乙素；抗帕金森；防止神经元损伤；抗类风湿关节炎；抗肿瘤
KeyWord	Glaucocalyxin B; Anti-parkinsonian; Prevent neuronal damage; Anti-rheumatoid arthritis; Anti-tumor
基金项目
页码	1-4

参考文献
相关文献

[1] 许薇. 蓝萼乙素对脂多糖诱导的帕金森病模型的神经保护作用及机制研究
[D]. 中国医科大学, 2018.

[2] Liu Y, Wu X, An J, Lv W, Geng Y, Lou T, Zhang Y. Glaucocalyxin B protects against oxygen-glucose-depriva

-tion/ reperfusion-induced neuronal injury in PC-12 cells
[J]. J Cell Biochem, 2018, 120(4): 6137- 6144.

[3] Gan P, Zhang L, Chen Y, Zhang Y, Zhang F, Zhou X, Zhang X, Gao B, Zhen X, Zhang J, Zheng LT. Anti- inflammatory effects of glaucocalyxin B in microglia cells
[J]. J Pharmacol Sci, 2015, 128(1): 35- 46.

[4] Abeles AM, Pillinger MH. The role of the synovial fibroblast in rheumatoid arthritis: cartilage destruction and the regulation of matrix metalloproteinases
[J]. Bull NYU Hosp Jt Dis, 2006, 64: 20- 24.

[5] Han C, Yang Y, Sheng Y, Wang J, Zhou X, Li W, Guo L, Zhang C, Ye Q. Glaucocalyxin B inhibits cartilage inflammatory injury in rheumatoid arthritis by regulating M1 polarization of synovial macrophages through NF-κB pathway
[J]. Aging (Albany NY), 2021, 13(18): 22544- 22555.

[6] 梁露露. 蓝萼乙素通过增加ROS诱导宫颈癌细胞生长抑制、凋亡和自噬的机制研究
[D].新乡医学院, 2022. DOI: 10. 27434/ d. cnki. gxxyc. 2022. 000179.

[7] 白洁宇. 蓝萼乙素对宫颈癌细胞HeLa、SiHa增殖抑制作用及其机制研究
[D]. 新乡医学院, 2016.

[8] 刘莹莹, 潘莹, 申芳芳, 白洁宇, 何全中. 蓝萼乙素对宫颈癌细胞迁移与侵袭影响作用机制
[J]. 中华肿瘤防治杂志, 2019, 26(04): 212- 220.

[9] 刘莹莹. 蓝萼乙素通过JNK和p38 MAPK通路诱导人宫颈癌细胞凋亡和细胞周期阻滞
[D].新乡医学院,2019. DOI: 10. 27434/d. cnki. gxxyc. 2019. 000215.

[10] 千文君. 蓝萼乙素对人宫颈癌裸鼠移植瘤抑制作用的研究
[D]. 新乡医学院, 2017.

[11] Ur Rahman MS, Zhang L, Wu L, Xie Y, Li C, Cao J. Sensitization of gastric cancer cells to alkylating agents by glaucocalyxin B via cell cycle arrest and enhanced cell death
[J]. Drug Des Devel Ther, 2017, 11: 2431- 2441.

[12] 吴元肇, 金早. 蓝萼乙素对三阴性乳腺癌MDA-MB-231细胞增殖、迁移及侵袭的影响
[J].中国中西医结合外科杂志, 2020, 26(04): 589- 594.

引用本文

王明鑫智,王镜超,权泉,金成浩*. 蓝萼乙素药理作用及其分子机制研究进展 [J]. 现代生命科学研究. 2023; 4; (1). 1 - 4.

文献评论

相关学者

相关机构