脂肪细胞分化的调控机制及其对机体代谢的影响

Regulation mechanism of adipocyte differentiation and its effect on metabolism

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DOI 10.12208/j.ijcr.20230108
刊名
International Journal of Clinical Research
年,卷(期) 2023, 7(3)
作者
作者单位

新乡医学院基础医学院 河南新乡 新乡市肝肠肿瘤免疫检查点药物研发工程中心 河南新乡 ;
新乡医学院基础医学院 河南新乡 ;

摘要
肥胖是目前世界性的健康问题之一,常伴随有胰岛素抵抗、血脂异常、肝脂肪变性、凝血病和高血压等。肥胖是由于脂肪细胞的数目增多或单个细胞体积增大引起的。脂肪细胞在能量储存中起到了关键作用,同时对机体能量代谢平衡也产生了重要影响。事实上,脂肪细胞的增大增多可以有效地隔离脂质防止对其他组织,如肌肉、肝脏和心脏中的脂质堆积,这也与肥胖相关的病理状态下维持代谢功能密切相关。这篇综述将对脂肪细胞分化的调控机制进行探讨,并讨论其对机体代谢平衡的影响。
Abstract
Obesity is one of the worldwide health problems, which is often accompanied by insulin resistance, dyslipidemia, hepatic steatosis, coagulation and hypertension. Adipocytes not only play a key role in energy storage, but also have an important impact on the balance of energy metabolism. In fact, the increase of adipocytes can effectively isolate lipids and prevent the accumulation of lipids in other tissues, such as muscle, liver and heart, which is also closely related to the maintenance of metabolic function in obesity-related pathological conditions. This review will explore the regulatory mechanism of adipocyte differentiation and discuss the effect of adipocytes on metabolic balance.
关键词
肥胖;脂肪细胞;细胞分化;代谢平衡
KeyWord
Obesity;Adipocyte;Cell differentiation;Metabolic balance
基金项目
页码 1-8
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李滟镕,孙一凡,余飘,于莉莉*. 脂肪细胞分化的调控机制及其对机体代谢的影响 [J]. 国际临床研究杂志. 2023; 7; (3). 1 - 8.

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