| Abstract |
Objective To explore the value of C-reactive protein (CRP), procalcitonin (PCT), blood lactic acid (LAC) and acute physiological and chronic health status score (APACHEⅡ) in the diagnosis of sepsis patients and the analysis of the severity of sepsis. Methods From January 2019 to December 2020, 42 patients with sepsis who met the diagnostic criteria of Sepsis-3 in ICU of Cangzhou Hospital of Integrated Traditional Chinese and Western Medicine in Hebei Province were selected, including 18 patients in septic shock group, 10 patients in severe sepsis group and 12 patients in sepsis group. In the same period, 19 patients in non-infectious SIRS group and 20 patients with non-septic infection were selected as control group. The values of APACHEⅡ score, PCT, CRP and LAC in each group were statistically analyzed and compared. Then the unconditional Logistic stepwise regression model was used to make single-factor and multi-factor statistical analysis for each group, and the receiver operating characteristic curve (ROC) curve was drawn and the diagnostic values of PCT, LAC, CRP and APACHEⅡ score for sepsis patients were compared respectively. Results The results of univariate statistical analysis showed that age, sex ratio, body temperature, leukocyte, neutrophil ratio, neutrophil and platelet in each group had no correlation with the diagnosis and severity of sepsis (P > 0.05). APACHEⅡ score, CRP, LAC and PCT were correlated with the severity of the disease (P <0.05). Logistic stepwise regression analysis showed that PCT, APACHE II, CRP and LAC were independent risk factors for the diagnosis of sepsis (P <0.05), and the area under PCT curve was the largest. There were significant differences in the scores of CRP, PCT, LAC and APACHEⅡ among patients with different severity (P<0.05), and the scores of CRP, PCT, LAC and APACHEⅡ increased significantly with the increase of patients severity (P<0.05). PCT, CRP, LAC and APACHEⅡ ⅱ scores were positively correlated with each other (P<0.05). Conclusion CRP, PCT, LAC and APACHEⅡ scores have high application value in the diagnosis of sepsis and the evaluation of its severity.
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