International Journal of Clinical Research

Objetive To observe the clinical efficacy of Huaihua powder retention enema combined with mesalazine in the treatment of damp-heat ulcerative colitis. Methods From October 2021 to October 2022, 56 patients with damp-heat ulcerative colitis admitted to the Department of Anorectal Diseases of Hubei Provincial Hospital of Traditional Chinese Medicine were selected as the study subjects, and randomly divided into an experimental group (28 cases) and a control group (28 cases) according to a random number table method. The control group was administered orally with mesalazine enteric coated tablets (4 times a day, 1 g each time), and combined with mesalazine enema liquid (1 time a day, 4 g each time), On this basis, the experimental group was added with Huaihua Sanjian Decoction for retention enema, and the score changes, clinical efficacy, and days required for symptom relief in the modified Mayo scoring system and Mayo endoscopic scoring system for ulcerative colitis activity in the two groups were compared. Results After treatment, the modified Mayo score and Mayo endoscopy score of patients in the experimental group were slightly lower than those in the control group, and the days of symptom relief in the experimental group were significantly lower than those in the control group (t=2.54, P=0.003); The total effective rate in the test group was 92.9%, and the total effective rate in the control group was 89.3%. The two groups were compared using rank sum test (P=0.679, P>0.05), and the difference was not statistically significant. Conclusion Huaihua powder liquid retention enema combined with mesalazine can significantly improve the clinical symptoms of patients with damp-heat ulcerative colitis, and can improve their clinical symptoms in a shorter time, improving their quality of life.

Huaihua Powder; Mesalazine; Ulcerative Colitis; TCM treatment