| Abstract |
Objective To conduct clinical imaging and pathological analysis of isolated fibrous tumors of the central nervous system in order to provide help and support for diagnosis and treatment. Methods 54 patients with isolated fibrous neoplasms of central nervous system diagnosed by pathological diagnosis were studied. The imaging, histomorphology and immunohistochemical characteristics of the patients were analyzed and summarized. Results According to the study analysis, among these patients, 25 were male and 29 were female, ranging in age from 16 to 67 years old. Among them, 45 patients had tumors located in the intracranial region, and 9 patients had tumors in the spinal canal region. The tumor boundaries of most patients were relatively clear. In MRI signal manifestations, T1WI was dominated by low signal, accounting for about (47/54), while T2WI was generally characterized by uneven signals with high signal and mixed signals. Obvious flaky and slightly longer T1 and slightly longer T2 edema areas could be seen in the brain tissue area around the lesion. T1WI enhanced scan showed more obvious uniform enhancement. Among the patients with intracranial tumors, the number of patients with peritumoral brain tissue edema was 18, the number of patients with venous sinus invasion was 11, the number of patients with bone destruction was 10, and the number of patients with meningeal tail sign was 6. According to the histopathological diagnosis results, there were 27 patients with grade 1, 14 patients with grade 2 and 13 patients with grade 3. The results of immunohistochemical examination showed that STAT6, Bcl-2, CD99 and Vimentin were generally positive, among which CD32 and Ki-67 index levels were high, while other indexes were low. GFAP, SOX10 and CK were mainly negative. During the follow-up period of 1 to 6 years, it was found that the disease control status of the vast majority of patients was relatively good, and only 7 patients with incomplete resection had local progression and distant metastasis. Conclusion For isolated fibrous neoplasms of the central nervous system, the meningeal tail sign is relatively rare, while the rate of peritumoral edema is relatively high, and the invasion rate of venous sinus and skull is relatively high, which belong to the typical imaging features. Finally, in the results of STAT6, Bcl-2, CD99, CD34, Vimentin and other indicators, the positive expression rate is very high, which belongs to typical pathological characteristics. Therefore, it can be seen from these characteristic results that the organic combination of imaging detection results and immunohistochemistry plays an important role in improving the diagnostic efficiency and quality.
|