MCP-1在不同疾病中的作用-国际临床研究杂志-CSCIED科技核心评价数据库-手机版

MCP-1在不同疾病中的作用

The role of MCP-1 in different diseases

ES评分 0 浏览量：1584 下载量：0

DOI	10.12208/j.ijcr.20230283
刊名	国际临床研究杂志 International Journal of Clinical Research
年，卷(期)	2023, 7(7)
作者	王万涛,赵广阳*,
作者单位	佳木斯大学附属第一医院黑龙江佳木斯 ;
摘要	MCP-1（单核细胞化学引诱蛋白-1），也称为趋化因子（CC-motif）配体2（CCL2），来自CC趋化因子家族。它在炎症发生发展过程中起着重要的作用，它可产生或增强其他炎症因子/细胞的表达。它通过诱导炎症细胞（如单核细胞/巨噬细胞和其他细胞因子）向炎症部位的迁移和浸润的主要机制导致许多疾病的发生发展。MCP-1已被直接或间接地归咎于许多疾病的发病机制，如心血管疾病、呼吸系统疾病、神经炎症性疾病等。本综述将侧重于MCP-1在各种疾病病理中的参与和作用。
Abstract	MCP-1 (monocyte chemoattractant protein-1), also known as chemokine (CC-motif) ligand 2 (CCL2), comes from the CC chemokine family. It plays an important role in the development of inflammation, which can produce or enhance the expression of other inflammatory factors/cells. It leads to the development of many diseases through the main mechanism of inducing the migration and infiltration of inflammatory cells (such as monocytes/macrophages and other cytokines) to the site of inflammation. MCP-1 has been directly or indirectly attributed to the pathogenesis of many diseases, such as cardiovascular diseases, respiratory diseases, neuroinflammatory diseases, etc. This review will focus on the involvement and role of MCP-1 in the pathology of various diseases.
关键词	趋化因子；炎症；疾病病理；作用
KeyWord	Chemokines; Inflammation; Disease pathology; Role
基金项目
页码	76-79

参考文献
相关文献

[1] A. Paulrayer, A. Adithan, J.H. Lee, K.H. Moon, D.G. Kim, S.Y. Im, C.W. Kang, N.S. Kim, J.H. Kim. Aronia melanocarpa (Black Chokeberry) reduces ethanol-induced gastric damage via regulation of HSP-70, NF-kappaB, and MCP-1 signaling. Int. J. Mol. Sci., 18 (6) (2017).

[2] Y. Taghavi, G. Hassanshahi, N.G. Kounis, I. Koniari, H. Khorramdelazad. Monocyte chemoattractant protein-1 (MCP-1/CCL2) in diabetic retinopathy: latest evidence and clinical considerations. J. Cell Commun. Signal, 13 (4) (2019), pp. 451-462.

[3] Y. Chen, J. Wang, C. Liu, L. Su, D. Zhang, J. Fan, Y. Yang, M. Xiao, J. Xie, Y. Xu, Y. Li, S. Zhang. IP-10 and MCP-1 as biomarkers associated with disease severity of COVID-19. Mol. Med., 26 (1) (2020), p. 97.

[4] X.H. Guo, Z. Bai, B. Qiang, F.H. Bu, N. Zhao. Roles of monocyte chemotactic protein 1 and nuclear factor-kappaB in immune response to spinal tuberculosis in a New Zealand white rabbit model. Braz. J. Med. Biol. Res., 50 (3) (2017), Article e5625.

[5] W.J. Lee, Y.C. Liao, Y.F. Wang, I.F. Lin, S.J. Wang, J.L. Fuh. Plasma MCP-1 and cognitive decline in patients with Alzheimer's disease and mild cognitive impairment: A two-year follow-up study. Sci. Rep., 8 (1) (2018), p. 1280

[6] P.A. Klimiuk, S. Sierakowski, R. Latosiewicz, J. Skowronski, J.P. Cylwik, B. Cylwik, J. Chwiecko. Histological patterns of synovitis and serum chemokines in patients with rheumatoid arthritis. J. Rheumatol., 32 (9) (2005), pp. 1666-1672.

引用本文

王万涛,赵广阳*. MCP-1在不同疾病中的作用 [J]. 国际临床研究杂志. 2023; 7; (7). 76 - 79.

文献评论

相关学者

相关机构