肠道微生态失衡与非酒精性脂肪肝发生发展的相关研究进展-国际临床研究杂志-CSCIED科技核心评价数据库-手机版

肠道微生态失衡与非酒精性脂肪肝发生发展的相关研究进展

Research progress on the relationship between Intestinal microecological imbalance and the occurrenceand development of Nonalcoholic fatty liver disease

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DOI	10.12208/j.ijcr.20231289
刊名	国际临床研究杂志 International Journal of Clinical Research
年，卷(期)	2023, 7(8)
作者	张秋心,郑盛*,
作者单位	大理大学第二附属医院消化内科云南昆明 ;
摘要	肠道微生态（Intestinal microecology， IM）是由肠道微生物群、肠道黏膜和肠道免疫系统组成的极其复杂的生态系统。非酒精性脂肪肝（nonalcoholic fatty liver disease，NAFLD）是指在没有过量饮酒（男性每天≥30g，女性每天≥20g）或其他慢性肝病的情况下，存在超过5%的相关肝细胞出现脂肪变性，包括一系列广泛的表现，从单纯的脂肪变性到非酒精性脂肪性肝炎（Nonalcoholic steatohepatitis，NASH）、纤维化，最终发展为肝硬化甚至肝细胞癌。目前多项研究表明肠道微生态失衡与非酒精性脂肪肝的发生发展有着密切联系，本文就肠道微生态失衡与非酒精性脂肪肝的发生发展相关机制进行综述，并总结肠道微生态对NAFLD的治疗性预期，以期对NAFLD的预防和治疗提供依据。
Abstract	Intestinal microecology,(IM) is an extremely complex ecosystem composed of intestinal microflora, intestinal mucosa and intestinal immune system. Non-alcoholic fatty liver disease (NAFLD) means that more than 5% of related liver cells have steatosis without excessive drinking (male ≥30g per day, female ≥20g per day) or other chronic liver diseases, including a wide range of manifestations, ranging from simple steatosis to Nonalcoholic steatohepatitis (NASH), fibrosis and so on. At present, many studies show that intestinal microecological imbalance is closely related to the occurrence and development of nonalcoholic fatty liver disease. This paper reviews the mechanism of intestinal microecological imbalance and the occurrence and development of nonalcoholic fatty liver disease, and summarizes the therapeutic expectation of intestinal microecology on NAFLD, in order to provide basis for the prevention and treatment of NAFLD.
关键词	肠道微生态；非酒精性脂肪肝；非酒精性脂肪性肝炎；肝硬化；肝癌
KeyWord	Intestinal microecology nonalcoholic; Nonalcoholic fatty liver disease; Nonalcoholic steatohepatitis; Liver cirrhosis; Hepatoma
基金项目
页码	16-21

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引用本文

张秋心,郑盛*. 肠道微生态失衡与非酒精性脂肪肝发生发展的相关研究进展 [J]. 国际临床研究杂志. 2023; 7; (8). 16 - 21.

文献评论

刘**南昌大学****** 已认证✔

2025-12-05 11:29:09

肠道微生态失衡在NAFLD发生发展中的关键作用是热点，肠-肝轴机制及菌群调节为NAFLD的防治提供了新视角，值得深入研究

杜**新疆医科****** 已认证✔

2025-09-17 10:15:27

本文系统综述了肠道微生态失衡在NAFLD发生发展中的关键作用，强调了肠-肝轴机制及菌群调节的治疗潜力，为NAFLD的防治提供了新视角，具有重要的临床参考价值。

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