International Journal of Clinical Research

Objective In order to improve the therapeutic effect of cerebral thrombosis and improve the degree of neurological impairment, the clinical application value of simvastatin combined with aspirin was discussed. Methods A total of 112 patients with cerebral thrombosis were selected for comparative experiment and divided into groups by blind sampling. 56 patients in each control group and observation group were given aspirin during treatment, while the latter combined with simvastatin on this basis, and the clinical effects of the two groups were compared. Results Compared with the control group, the overall therapeutic effect of the observation group was higher. Before treatment, there was no difference in IMT and plaque area between the two groups (P > 0.05), but after treatment, the plaque area and carotid intima-media thickness in the observation group were lower than those in the control group (P < 0.05). At the same time, the NIHSS score and Barthel index before and after treatment were compared between the two groups (P > 0.05) and (P < 0.05), respectively, and there was no statistical significance in the assessment before treatment. After treatment, the score of neurological impairment and the score of daily living ability in the observation group were significantly lower than those in the control group and before treatment. Conclusion For patients with cerebral thrombosis, simvastatin combined with aspirin during treatment can not only effectively reduce the degree of neurological impairment, but also reduce the area and thickness of carotid artery plaque to the greatest extent, effectively improve their daily life ability, and the therapeutic effect is better.

Simvastatin; Aspirin cerebral thrombus; Effect; Neurological impairment