International Journal of Nursing Research

Objective: To observe the effect of plasma transfusion during rehabilitation on severe patients with novel coronavirus (COVID-19), and to discuss and summarize the main points of nursing. Methods: To retrospectively analyze the clinicaldata of 21 COVID-19 severe patients receiving convalescent plasma infusion therapy from March 1 to April 1, 2020.Observe Leukocytes, lymphocytes,CRP，IL-6, viral antibodies, pharyngeal swabs, nucleic acid test results, chest CT, respiratory symptoms, and summarize the nursing points related to plasma transfusion. Results: There was no death and no transfusion-related adverse reactions in patients treated with plasma during the rehabilitation period; the antibody levels of the patients increased to varying degrees, especially IgG increased significantly, P＜0.05; inflammation levels (CRP and IL-6), white blood cells, Lymphocytes were significantly decreased, P＜0.05; respiratory symptoms were improved, chest CT was stable or absorbed earlier. Conclusion: Plasma infusion during the rehabilitation period is safe and feasible. It can increase the antibody level of COVID-19 severe patients to varying degrees, reduce the levels of inflammatory factors, improve the levels of white blood cells and lymphocytes, and improve the respiratory symptoms of patients. There is currently no specific treatment for COVID-19， Plasma infusion as a new treatment method requires close cooperation of nursing, preparation for infusion in nursing, precise process control and observation and recording of later effects are most important.

Novel coronavirus disease; plasma during rehabilitation; nursing