子宫内膜异位症中的免疫细胞研究现状-国际临床研究杂志-CSCIED科技核心评价数据库-手机版

子宫内膜异位症中的免疫细胞研究现状

The research status of immune cells in endometriosis

ES评分 0 浏览量：556 下载量：1

DOI	10.12208/j.ijcr.20230336
刊名	国际临床研究杂志 International Journal of Clinical Research
年，卷(期)	2023, 7(10)
作者	刘君君¹,刘义¹,王琼华²,杨天兰²,黄东晖³*,
作者单位	1 华中科技大学同济医学院附属协和医院湖北武汉 ; 2 临沧市临翔区妇幼保健院云南临沧 ; 3 华中科技大学同济医学院生殖健康研究所湖北武汉
摘要	子宫内膜异位症（EMS）作为一种在育龄妇女中发病广泛、严重影响患者生育能力和生活质量的妇科疾病，其发病机制至今仍未具体阐明。大量研究表明，子宫内膜异位症患者的异位子宫内膜中存在免疫系统紊乱，免疫细胞与子宫内膜异位症发病机制密切相关已是公认的事实。本文从子宫内膜异位症中的免疫细胞出发，系统综述了近几年关于子宫内膜异位症病程中免疫细胞的研究进展，为未来研究子宫内膜异位症的发病机制及EMS的临床诊断和治疗提供思路。
Abstract	Endometriosis (EMS) is a gynecological disease widely occurring in women of childbearing age, which seriously affects the fertility and quality of life of patients. Its pathogenesis has not been clarified yet. A large number of studies have shown that the disorder of immune system exists in the ectopic endometrium of patients with endometriosis, and it is a recognized fact that immune cells are closely related to the pathogenesis of endometriosis. Based on the immune cells in endometriosis, this paper systematically reviewed the research progress of immune cells in the course of endometriosis in recent years, providing ideas for the future study of the pathogenesis of endometriosis and the clinical diagnosis and treatment of EMS.
关键词	子宫内膜异位症（EMS）；免疫细胞；发病机制
KeyWord	Endometriosis (EMS); Immune cells; Pathogenesis
基金项目
页码	54-58

参考文献
相关文献

[1] Symons LK, Miller JE, Kay VR, et al. The Immunopathophysiology of Endometriosis. Trends Mol Med. 2018; 24(9):748-762.

[2] Poli-Neto OB, Meola J, Rosa-E-Silva JC, Tiezzi D. Transcriptome meta-analysis reveals differences of immune profile between eutopic endometrium from stage I-II and III-IV endometriosis independently of hormonal milieu. Sci Rep. 2020 Jan 15;10(1):313.

[3] Suen JL, Chang Y, Shiu YS, Hsu CY, Sharma P, Chiu CC, Chen YJ, Hour TC, Tsai EM. IL-10 from plasmacytoid dendritic cells promotes angiogenesis in the early stage of endometriosis. J Pathol. 2019 Dec;249(4):485-497.

[4] Hey-Cunningham AJ, Wong C, Hsu J, Fromm PD, Clark GJ, Kupresanin F, Miller EJ, Markham R, McGuire HM. Comprehensive analysis utilizing flow cytometry and immunohistochemistry reveals inflammatory changes in local endometrial and systemic dendritic cell populations in endometriosis. Hum Reprod. 2021 Jan 25;36(2): 415-428.

[5] Vallvé-Juanico J, Houshdaran S, Giudice LC. The endometrial immune environment of women with endometriosis. Hum Reprod Update. 2019 Sep 11;25(5): 564-591.

[6] Izumi G, Koga K, Takamura M, Makabe T, Nagai M, Urata Y, Harada M, Hirata T, Hirota Y, Fujii T, Osuga Y. Mannose receptor is highly expressed by peritoneal dendritic cells in endometriosis. Fertil Steril. 2017 Jan;107(1):167-173.e2.

[7] Vallvé-Juanico J, Houshdaran S, Giudice LC. The endometrial immune environment of women with endometriosis. Hum Reprod Update. 2019 Sep 11;25(5): 564-591.

[8] Ma J, Zhang L, Zhan H, Mo Y, Ren Z, Shao A, Lin J. Single-cell transcriptomic analysis of endometriosis provides insights into fibroblast fates and immune cell heterogeneity. Cell Biosci. 2021 Jul 7;11(1):125.

[9] Laganà AS, Salmeri FM, Ban Frangež H, Ghezzi F, Vrtačnik-Bokal E, Granese R. Evaluation of M1 and M2 macrophages in ovarian endometriomas from women affected by endometriosis at different stages of the disease. Gynecol Endocrinol. 2020 May; 36(5):441-444.

[10] Vallvé-Juanico J, Santamaria X, Vo KC, Houshdaran S, Giudice LC. Macrophages display proinflammatory phenotypes in the eutopic endometrium of women with endometriosis with relevance to an infectious etiology of the disease. Fertil Steril. 2019 Dec;112(6):1118-1128.

[11] Hogg C, Horne AW, Greaves E. Endometriosis-Associated Macrophages: Origin, Phenotype, and Function. Front Endocrinol (Lausanne). 2020;11:7. Published 2020 Jan 23.

[12] Hogg C, Panir K, Dhami P, Rosser M, Mack M, Soong D, Pollard JW, Jenkins SJ, Horne AW, Greaves E. Macrophages inhibit and enhance endometriosis depending on their origin. Proc Natl Acad Sci U S A. 2021 Feb 9;118(6): e2013776118.

[13] Ramírez-Pavez TN, Martínez-Esparza M, Ruiz-Alcaraz AJ, Marín-Sánchez P, Machado-Linde F, García-Peñarrubia P. The Role of Peritoneal Macrophages in Endometriosis. Int J Mol Sci. 2021 Oct 6;22(19):10792.

[14] Li Q, Yuan M, Jiao X, Huang Y, Li J, Li D, Ji M, Wang G. M1 Macrophage-Derived Nanovesicles Repolarize M2 Macrophages for Inhibiting the Development of Endometriosis. Front Immunol. 2021 Jul 20;12:707784.

[15] Jeung I, Cheon K, Kim MR. Decreased Cytotoxicity of Peripheral and Peritoneal Natural Killer Cell in Endometriosis. Biomed Res Int. 2016;2016:2916070.

[16] hiruchelvam U, Wingfield M, O'Farrelly C. Increased uNK Progenitor Cells in Women With Endometriosis and Infertility are Associated With Low Levels of Endometrial Stem Cell Factor. Am J Reprod Immunol. 2016 Apr; 75(4):493-502.

[17] Ścieżyńska A, Komorowski M, Soszyńska M, Malejczyk J. NK Cells as Potential Targets for Immunotherapy in Endometriosis. J Clin Med. 2019 Sep 14;8(9):1468.

[18] Du Y, Liu X, Guo SW. Platelets impair natural killer cell reactivity and function in endometriosis through multiple mechanisms. Hum Reprod. 2017 Apr 1;32(4):794-810.

[19] Takamura M, Koga K, Izumi G, Hirata T, Harada M, Hirota Y, Hiraike O, Fujii T, Osuga Y. Simultaneous Detection and Evaluation of Four Subsets of CD4+ T Lymphocyte in Lesions and Peripheral Blood in Endometriosis. Am J Reprod Immunol. 2015 Dec; 74(6):480-6.

[20] Gogacz M, Winkler I, Bojarska-Junak A, Tabarkiewicz J, Semczuk A, Rechberger T, Adamiak A. Increased percentage of Th17 cells in peritoneal fluid is associated with severity of endometriosis. J Reprod Immunol. 2016 Sep; 117:39-44.

[21] Khan KN, Yamamoto K, Fujishita A, Muto H, Koshiba A, Kuroboshi H, Saito S, TeramukaiS, Nakashima M, Kitawaki J. Differential Levels of Regulatory T Cells and T-Helper-17 Cells in Women With Early and Advanced Endometriosis. J Clin Endocrinol Metab. 2019;104(10): 4715-4729.

[22] Pashizeh F, Mansouri R, Davari-Tanha F, Hosseini R, Asgari Z, Aghaei H, Najafi Arbastan F, Rajaei S. Alterations of CD4+T Cell Subsets in Blood and Peritoneal Fluid in Different Stages of Endometriosis. Int J Fertil Steril. 2020 Oct;14(3):201-208.

[23] de Barros IBL, Malvezzi H, Gueuvoghlanian-Silva BY, Piccinato CA, Rizzo LV, Podgaec S. "What do we know about regulatory T cells and endometriosis? A systematic review". J Reprod Immunol. 2017 Apr;120:48-55.

[24] Tanaka Y, Mori T, Ito F, Koshiba A, Takaoka O, Kataoka H, Maeda E, Okimura H, Mori T, Kitawaki J. Exacerbation of Endometriosis Due To Regulatory T-Cell Dysfunction. J Clin Endocrinol Metab. 2017 Sep 1;102(9): 3206-3217.

[25] Olkowska-Truchanowicz J, Sztokfisz-Ignasiak A, Zwierzchowska A, Janiuk I, Dąbrowski F, Korczak -Kowalska G, Barcz E, Bocian K, Malejczyk J. Endometriotic Peritoneal Fluid Stimulates Recruitment of CD4+CD25highFOXP3+ Treg Cells. J Clin Med. 2021 Aug 25;10(17):3789.

[26] Olkowska-Truchanowicz J, Białoszewska A, Zwierzchows -ka A, Sztokfisz-Ignasiak A, Janiuk I, Dąbrowski F, Korczak-Kowalska G, Barcz E, Bocian K, Malejczyk J. Peritoneal Fluid from Patients with Ovarian Endometriosis Displays Immunosuppressive Potential and Stimulates Th2 Response. Int J Mol Sci. 2021 Jul 29;22(15):8134.

[27] Schmitz T, Hoffmann V, Olliges E, Bobinger A, Popovici R, Nößner E, Meissner K. Reduced frequency of perforin-positive CD8+ T cells in menstrual effluent of endometriosis patients. J Reprod Immunol. 2021 Nov;148: 103424.

[28] Osuga Y, Koga K, Hirota Y, Hirata T, Yoshino O, Taketani Y. Lymphocytes in endometriosis. Am J Reprod Immunol. 2011 Jan;65(1):1-10.

引用本文

刘君君,刘义,王琼华,杨天兰,黄东晖*. 子宫内膜异位症中的免疫细胞研究现状 [J]. 国际临床研究杂志. 2023; 7; (10). 54 - 58.

文献评论

李**暨南大学****** 已认证✔

2025-11-06 08:04:21

子宫内膜中不是免疫系统，是免疫微环境，部分表达不准确。文中首次出现EMS，需要有全称。文献引用不规范，较多未标注引用的参考文献。最近一项通过GO和KEGG富集分析，不规范，未指明测序来源的标本及数据，其结果可信程度难以判断。综述存在逻辑不清之处。如巨噬细胞，有活化类型，也有根据定位的不同类型，表述不清，读者理解起来易混乱。

相关学者

相关机构