International Journal of Nursing Research

Objective To systematically evaluate the impact of the concept of accelerated rehabilitation surgery on inflammatory stress and quality of life in patients after laparoscopic radical gastric cancer surgery. Methods From January 2015 to January 2023, relevant literature on the comparative analysis of the accelerated rehabilitation surgery concept(ERAS)and conventional rehabilitation program(CRAS)treatment for patients with laparoscopic gastric cancer after surgery was searched. The search databases included PubMed, Embase, Cochrane Libarary, CNKI, and Uyghur Wanfang. Two researchers conducted literature screening, data extraction and quality evaluation, and used RevMan5.3 software for Meta analysis. Results Finally, 8 articles were included, and the total number of cases was 538.There was a statistically significant difference in serum CRP levels between the two groups(Z=48.58,P<0.00001).The comparison of serum IL-6 levels between the two groups was statistically significant(Z=15.31, P<0.00001).The comparison of serum IL-8 levels between the two groups was statistically significant(Z=86.03, P<0.00001).The serum IL-10 levels of the two groups were compared, and the difference was statistically significant(Z=10.89, P<0.00001).There was a statistically significant difference in the quality of life between the two groups(Z=21.20, P<0.00001). Conclusion The ERAS regimen is safe and effective for patients after laparoscopic radical gastric cancer surgery. It can significantly reduce the postoperative inflammatory stress response and significantly improve the quality of life of patients.

Accelerated rehabilitation surgery concept; Gastric cancer; Laparoscopic radical gastrectomy; Inflammatory stress; Quality of life; Publication bias; Meta analysis