International Journal of Clinical Research

Objective To investigate the expression of telomere/telomerase in pelvic connective tissue and explore the mechanism of telomere/telomerase involvement in the occurrence of pelvic organ prolapse (POP) at the gene level. Methods 40 patients aged 35 to 75 were randomly selected. The experimental group consisted of patients who underwent hysterectomy due to uterine prolapse; The control group consisted of patients who underwent total hysterectomy due to benign uterine diseases. The expression of telomerase, COLI, COLIII and other indicators in the tissue cells of the uterine sacral ligament and round ligament tissues of surgical specimens was detected using experimental methods such as Masson staining and IHC. Results There was a statistical difference in the expression of COLL I and COLL III between the two groups, but there was no significant difference in TERT expression. Conclusion The expression of COLLI and COLLIII in the uterine ligaments of patients with pelvic organ prolapse has decreased significantly, but the effect of telomeres in the formation of pelvic organ prolapse needs to be further experimentally verified.

Pelvic organ prolapse; COLL I; COLL III; Telomere; TERT