International Journal of Pediatrics Research

Objective To explore the significance of exhaled nitric oxide (FENO) and eosinophil (EOS) levels in the diagnosis of early wheezing in children. Methods 78 wheezing infants aged 12-36 months, including 37 males and 41 females, were selected from the Department of Pediatrics, the first affiliated Hospital of Baotou Medical College from September 1, 2020 to April 1, 2022. 68 children who met the criteria of API evaluation were selected from 78 wheezing children. According to the results of API, 68 children were divided into API positive group (n = 35) and API negative group (n = 33). SPSS25.0 statistical software was used to compare the levels of FENO and EOS, high proportion of FENO and general data between the two groups, and to explore the correlation between EOS and FENO in API positive group by Pearson correlation analysis. Results there was no significant difference in general data between the two groups. The levels of FeNO, EOS and the proportion of high FeNO in the positive group were significantly higher than those in the negative group. The level of FENO in the API (+) group was positively correlated with EOS. Conclusion FENO can reflect the level of eosinophilic inflammation of the airway and predict the risk of progression to asthma combined with the level of EOS. Therefore, combining the levels of FENO and EOS in children with asthma can not only assist in the early prediction and diagnosis of asthma, but also reflect the type and severity of airway inflammation in children, so as to better distinguish the types of asthma, give standardized treatment, and then predict the response to anti-inflammatory treatment.

Wheezing in children; exhaled nitric oxide; eosinophils; asthma predictive index; correlation