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Current Practice of Genetics Research of Psychiatric Disorders

Current Practice of Genetics Research of Psychiatric Disorders

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DOI	10.20900/jpbs.20160001
刊名	Journal of Psychiatry and Brain Science JPBS
年，卷(期)	2016, 1(1)
作者	Chunyu Liu*,Kay S. Grennan,Elliot S. Gershon,
作者单位	1 State Key Laboratory of Medical Genetics, Central South University, Changsha, China; 2 Department of Psychiatry, University of Illinois at Chicago, Chicago, USA; 3 Department of Psychiatry and Behavioral Neuroscience, The University of Chicago, Chicago, USA
Abstract	Incorporating a genetic component can be appealing to an investigator designing a new study of a neuropsychiatric disorder. After all, it is well known that most neuropsychiatric disorders are heritable to one degree or another. One may consider genetic study a simple process: draw blood from subjects, submit it to a service lab, get the genotypes back, and test them for an association with the phenotype(s) being studied. In reality, it is considerably more complicated than that. Putting aside the complexity of choosing the proper platforms for genotyping and phenotyping, there are a number of issues that must be addressed in the initial study design if the results are to be replicable and relevant to the current state of knowledge of the disorder in question. The three major issues are effect sizes, Type I error rates, and genetic and phenotypic heterogeneity.
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引用本文

Chunyu Liu*,Kay S. Grennan,Elliot S. Gershon. Current Practice of Genetics Research of Psychiatric Disorders, Journal of Psychiatry and Brain Science. 2016; 1; (1). https://doi.org/10.20900/jpbs.20160001.

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