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Decrease of gray matter volume in treatment-refractory schizophrenia patients

Decrease of gray matter volume in treatment-refractory schizophrenia patients

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DOI	10.20900/jpbs.20160003
刊名	Journal of Psychiatry and Brain Science JPBS
年，卷(期)	2016, 1(1)
作者	Xiaomeng Shi;Eugene Chao;Xiaolan Wang;Jing Sun1;Hui Yao,Xijia Xu,,,,*,
作者单位	1 Department of Psychiatry, Affiliated Nanjing Brain Hospital of Nanjing Medical University (Nanjing 210029); ; 2 Baylor College of Medicine.
Abstract	Objective To investigate the gray matter alterations in treatment-refractory schizophrenia (TRS) patients and to explore the correlations between gray matter alterations and clinical characteristics in these patients. Methods Voxel based morphometry (VBM) in conjunction with statistical parametric mapping on the structural magnetic resonance images of TRS patients (n=24) and healthy controls (n=21) was performed to assess differences between the two groups in gray matter volume(GMV). Results We found GMV decreased in the left olfactory, bilateral insula and right anterior cingulate of TRS patients compared to healthy controls (p<0.05, FWE corrected). However, we did not find any correlation between gray matter reduction and clinical characteristics in these patients. Conclusion TRS patients have GMV decreased in the left olfactory, bilateral insula and right anterior cingulate.
KeyWord	treatment-refractory schizophrenia; gray matter volume; voxel based morphometry (VBM)
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Xiaomeng Shi;Eugene Chao;Xiaolan Wang;Jing Sun;Hui Yao,Xijia Xu,,,,*. Decrease of gray matter volume in treatment-refractory schizophrenia patients, Journal of Psychiatry and Brain Science. 2016; 1; (1). https://doi.org/10.20900/jpbs.20160003.

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