JPBS

Background: Recently, several studies reported possible association between gene FKBP5 and schizophrenia (SCZ). Their results suggested that FKBP5 may link to stress and cognition in case of SCZ, which warranted further study in the field. Method: In this study, we performed a systematical literature review, focusing on FKBP5--brain region association studies and brain region--SCZ relations, with the purpose of identifying potential FKBP5 → brain → SCZ pathogenic pathways. Results: We identified over 1,500 references supporting the relation of four common brain regions that related to both FKBP5 and SCZ. These brain regions include hypothalamus, hippocampus, prefrontal cortex, amygdaloid. Analysis showed that FKBP5 affects the structure and function of these four brain regions with different mechanisms, which may in turn influence the pathogenesis of SCZ. Conclusion: Our results support the hypothesis that FKBP5 present linkage to the development of SCZ, which help to gain better understanding of the underlying FKBP5 → SCZ association mechanism.

FKBP5; Schizophrenia; hypothalamus; hippocampus; prefrontal cortex; amygdaloid