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A Possible Role for the FKBP5 Gene in Schizophrenia

A Possible Role for the FKBP5 Gene in Schizophrenia

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DOI	10.20900/jpbs.20160020
刊名	Journal of Psychiatry and Brain Science JPBS
年，卷(期)	2016, 1(5)
作者	Wang.Xiao.Lei*,,,,
作者单位	1 The Mental Health Center and the Psychiatric Laboratory, West China Hospital, Sichuan University, Chengdu, Sichuan, 610041, China; 2 Department of Biology Products, American Informatics Consultant LLC, Rockville, MD, 20852, USA; 3 Spark Energy LLC, Houston, TX 77253, USA
Abstract	Background: Recently, several studies reported possible association between gene FKBP5 and schizophrenia (SCZ). Their results suggested that FKBP5 may link to stress and cognition in case of SCZ, which warranted further study in the field. Method: In this study, we performed a systematical literature review, focusing on FKBP5--brain region association studies and brain region--SCZ relations, with the purpose of identifying potential FKBP5 → brain → SCZ pathogenic pathways. Results: We identified over 1,500 references supporting the relation of four common brain regions that related to both FKBP5 and SCZ. These brain regions include hypothalamus, hippocampus, prefrontal cortex, amygdaloid. Analysis showed that FKBP5 affects the structure and function of these four brain regions with different mechanisms, which may in turn influence the pathogenesis of SCZ. Conclusion: Our results support the hypothesis that FKBP5 present linkage to the development of SCZ, which help to gain better understanding of the underlying FKBP5 → SCZ association mechanism.
KeyWord	FKBP5; Schizophrenia; hypothalamus; hippocampus; prefrontal cortex; amygdaloid
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Wang.Xiao.Lei*,,,. A Possible Role for the FKBP5 Gene in Schizophrenia, Journal of Psychiatry and Brain Science. 2016; 1; (5). https://doi.org/10.20900/jpbs.20160020.

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