Identification and Validation Novel Risk Genes for Autism Spectrum Disorder – A Meta-Analysis-Journal of Psychiatry and Brain Science-CSCIED科技核心评价数据库-手机版

Identification and Validation Novel Risk Genes for Autism Spectrum Disorder – A Meta-Analysis

Identification and Validation Novel Risk Genes for Autism Spectrum Disorder – A Meta-Analysis

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DOI	10.20900/jpbs.20170002
刊名	Journal of Psychiatry and Brain Science JPBS
年，卷(期)	2017, 2(1)
作者	Dongbai.Liu,Zeya.Wang*,
作者单位	1 Department of Neurology, The First People's Hospital Affiliated to Soochow University, Suzhou, Jiangsu Province, 215006, China; 2 Department of Neurology, Jiangyin People's hospital. Jiangyin, Jiangsu Province, 214400, China; 3 Department of Statistics, Rice University, 6100 Main St. Duncan Hall 2124, Houston, TX 77005
Abstract	Background: Autism spectrum disorders (ASD) are classified as neurodevelopmental disorders. The aim of this study was to investigate the genetic risk of ASD by systematically reviewing the published literature and performing a meta-analysis.Method: A comprehensive search of electronic databases was completed using Illumina BaseSpace Correlation Engine. Seven ASD case/control bio-sets from three different studies were selected, including 61 ASD cases and 83 controls. The top ASD risk genes from meta-analysis were further analyzed with an online open source ASD genetic database. Pathway enrichment analysis (PEA) and network connectivity analysis (NCA) were conducted to identify potential functional association between novel target genes and ASD.
KeyWord	Meta-analysis; Autism Spectrum Disorder; ResNet Database; pathway enrichment analysis; network connectivity analysis.
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Dongbai.Liu,Zeya.Wang*. Identification and Validation Novel Risk Genes for Autism Spectrum Disorder – A Meta-Analysis, Journal of Psychiatry and Brain Science. 2017; 2; (1). https://doi.org/10.20900/jpbs.20170002.

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