Let’s Talk about the Association between Schizophrenia Polygenic Risk Scores and Cognition in Patients and the General Population: A Review-Journal of Psychiatry and Brain Science-CSCIED科技核心评价数据库-手机版

Let’s Talk about the Association between Schizophrenia Polygenic Risk Scores and Cognition in Patients and the General Population: A Review

Let’s Talk about the Association between Schizophrenia Polygenic Risk Scores and Cognition in Patients and the General Population: A Review

ES评分 0 浏览量：783 下载量：1

全文阅读下载引用收藏

DOI	10.20900/jpbs.20180012
刊名	Journal of Psychiatry and Brain Science JPBS
年，卷(期)	2018, 3(6)
作者	Sabrina K. Schaupp,Thomas G. Schulze,Monika Budde*,
作者单位	1 Institute of Psychiatric Phenomics and Genomics (IPPG), University Hospital, LMU Munich, Munich 80336, Germany; 2 Clinic for Psychiatry, Psychotherapy and Psychosomatics, Augsburg 86156, Germany.
Abstract	In the late 19th century, Emil Kraepelin divided endogenous psychosis into manic-depressive psychosis and dementia praecox. The latter term described individuals with schizophrenia and highlights cognitive deficits as a core feature of this illness. Since first degree relatives show lower cognitive performance than healthy controls, but better performance than patients, cognitive functions are discussed as potential endophenotypes for schizophrenia. During the last years, several studies have explored the relationship between schizophrenia polygenic risk scores and cognition both in individuals with psychiatric diseases and the general population. Current research shows mixed results for specific cognitive domains as well as general cognitive abilities and intelligence. These ambiguous results in parts might be due to the heterogeneity of neuropsychological tests used to measure various cognitive domains. Most studies are also underpowered, given the small to moderate effects of schizophrenia polygenic risk scores on cognition. As sufficient sample sizes become more and more available by international consortia and national registries, future studies will probably shed light on the biological relationship between schizophrenia and cognition.
KeyWord	psychosis; genomic profile score; cognitive performance; intelligence; endophenotype
基金项目
页码	-

参考文献
相关文献

1.Fusar-Poli P, Deste G, Smieskova R, Barlati S, Yung AR, Howes O, et al. Cognitive functioning in prodromal psychosis: a meta-analysis. Arch Gen Psychiatry. 2012; 69(6): 562–571.

2.Sitskoorn MM, Aleman A, Ebisch SJH, Appels MCM, Kahn RS. Cognitive deficits in relatives of patients with schizophrenia: a meta-analysis. Schizophr Res. 2004; 71(2–3): 285–295.

3.Hill SK, Reilly JL, Keefe RSE, Gold JM, Bishop JR, Gershon ES, et al. Neuropsychological impairments in schizophrenia and psychotic bipolar disorder: findings from the Bipolar-Schizophrenia Network on Intermediate Phenotypes (B-SNIP) study. Am J Psychiatry. 2013; 170(11): 1275–1284.

4.Xu G, Lin K, Rao D, Dang Y, Ouyang H, Guo Y, et al. Neuropsychological performance in bipolar I, bipolar II and unipolar depression patients: a longitudinal, naturalistic study. J Affect Disord. 2012; 136(3): 328–339.

5.Reichenberg A, Harvey PD, Bowie CR, Mojtabai R, Rabinowitz J, Heaton RK, et al. Neuropsychological function and dysfunction in schizophrenia and psychotic affective disorders. Schizophr Bull. 2009; 35(5): 1022–1029.

6.Szoke A, Meary A, Trandafir A, Bellivier F, Roy I, Schurhoff F, et al. Executive deficits in psychotic and bipolar disorders - implications for our understanding of schizoaffective disorder. Eur Psychiatry J Assoc Eur Psychiatr. 2008; 23(1): 20–25.

7.Torrent C, Martínez-Arán A, Amann B, Daban C, Tabarés-Seisdedos R, González-Pinto A, et al. Cognitive impairment in schizoaffective disorder: a comparison with non-psychotic bipolar and healthy subjects. Acta Psychiatr Scand. 2007; 116(6): 453–460.

8.Selzam S, Coleman JRI, Caspi A, Moffitt TE, Plomin R. A polygenic p factor for major psychiatric disorders. Transl Psychiatry. 2018; 8(1): 205.

9.Craddock N, Owen MJ. The Kraepelinian dichotomy—going, going... but still not gone. Br J Psychiatry. 2010; 196(2): 92–95.

10.Lynham AJ, Hubbard L, Tansey KE, Hamshere ML, Legge SE, Owen MJ, et al. Examining cognition across the bipolar/schizophrenia diagnostic spectrum. J Psychiatry Neurosci JPN. 2018; 43(4): 245–253.

11.Nuechterlein KH, Green MF, Kern RS, Baade LE, Barch DM, Cohen JD, et al. The MATRICS Consensus Cognitive Battery, part 1: test selection, reliability, and validity. Am J Psychiatry. 2008; 165(2): 203–213.

12.August SM, Kiwanuka JN, McMahon RP, Gold JM. The MATRICS Consensus Cognitive Battery (MCCB): clinical and cognitive correlates. Schizophr Res. 2012; 134(1): 76–82.

13.Hilker R, Helenius D, Fagerlund B, Skytthe A, Christensen K, Werge TM, et al. Heritability of Schizophrenia and Schizophrenia Spectrum Based on the Nationwide Danish Twin Register. Biol Psychiatry. 2018; 83(6): 492–498.

14.Pardiñas AF, Holmans P, Pocklington AJ, Escott-Price V, Ripke S, Carrera N, et al. Common schizophrenia alleles are enriched in mutation-intolerant genes and in regions under strong background selection. Nat Genet. 2018; 50(3): 381–389.

15.Purcell SM, Wray NR, Stone JL, Visscher PM, O’Donovan MC, Sullivan PF, et al. Common polygenic variation contributes to risk of schizophrenia and bipolar disorder. Nature. 2009; 460(7256), 748-752.

16.Wray NR, Lee SH, Mehta D, Vinkhuyzen AAE, Dudbridge F, Middeldorp CM. Research Review: Polygenic methods and their application to psychiatric traits. J Child Psychol Psychiatry. 2014; 55(10): 1068–1087.

17.Gottesman II, Shields J. Genetic theorizing and schizophrenia. Br J Psychiatry J Ment Sci. 1973; 122(566): 15–30.

18.Gottesman II, Gould TD. The endophenotype concept in psychiatry: etymology and strategic intentions. Am J Psychiatry. 2003; 160(4): 636–645.

19.Deary IJ, Johnson W, Houlihan LM. Genetic foundations of human intelligence. Hum Genet. 2009; 126(1): 215–232.

20.Plomin R, Deary IJ. Genetics and intelligence differences: five special findings. Mol Psychiatry. 2015; 20(1): 98–108.

21.Plomin R, von Stumm S. The new genetics of intelligence. Nat Rev Genet. 2018; 19(3): 148–159.

22.Savage JE, Jansen PR, Stringer S, Watanabe K, Bryois J, de Leeuw CA, et al. Genome-wide association meta-analysis in 269,867 individuals identifies new genetic and functional links to intelligence. Nat Genet. 2018; 50(7): 912–919.

23.Hubbard L, Tansey KE, Rai D, Jones P, Ripke S, Chambert KD, et al. Evidence of Common Genetic Overlap Between Schizophrenia and Cognition. Schizophr Bull. 2016; 42(3): 832–842.

24.Hill WD, Harris SE, Deary IJ. What genome-wide association studies reveal about the association between intelligence and mental health. Curr Opin Psychol. 2018; 27: 25–30.

25.Schizophrenia Working Group of the Psychiatric Genomics Consortium. Biological insights from 108 schizophrenia-associated genetic loci. Nature. 2014; 511(7510): 421–427.

26.Alloza C, Bastin ME, Cox SR, Gibson J, Duff B, Semple SI, et al. Central and non-central networks, cognition, clinical symptoms, and polygenic risk scores in schizophrenia. Hum Brain Mapp. 2017; 38(12): 5919–5130.

27.Nakahara S, Medland S, Turner JA, Calhoun VD, Lim KO, Mueller BA, et al. Polygenic risk score, genome-wide association, and gene set analyses of cognitive domain deficits in schizophrenia. Schizophr Res. 2018 ; 201: 393-399.

28.Ranlund S, Calafato S, Thygesen JH, Lin K, Cahn W, Crespo-Facorro B, et al. A polygenic risk score analysis of psychosis endophenotypes across brain functional, structural, and cognitive domains. Am J Med Genet Part B. 2018; 177(1): 21–34.

29.Shafee R, Nanda P, Padmanabhan JL, Tandon N, Alliey-Rodriguez N, Kalapurakkel S, et al. Polygenic risk for schizophrenia and measured domains of cognition in individuals with psychosis and controls. Transl Psychiatry. 2018; 8(1): 78.

30.van Os J, van der Steen Y, Islam MA, Gülöksüz S, Rutten BP, Simons CJ, et al. Evidence that polygenic risk for psychotic disorder is expressed in the domain of neurodevelopment, emotion regulation and attribution of salience. Psychol Med. 2017; 47(14): 2421–2437.

31.Terwisscha van Scheltinga AFT, Bakker SC, van Haren NEM, Derks EM, Buizer-Voskamp JE, Cahn W, et al. Schizophrenia genetic variants are not associated with intelligence. Psychol Med. 2013; 43(12): 2563–70.

32.Walton E, Turner J, Gollub RL, Manoach DS, Yendiki A, Ho B-C, et al. Cumulative genetic risk and prefrontal activity in patients with schizophrenia. Schizophr Bull. 2013; 39(3): 703–711.

33.Wang S-H, Hsiao P-C, Yeh L-L, Liu C-M, Liu C-C, Hwang T-J, et al. Polygenic risk for schizophrenia and neurocognitive performance in patients with schizophrenia. Genes Brain Behav. 2018; 17(1): 49–55.

34.Whalley HC, Adams MJ, Hall LS, Clarke T-K, Fernandez-Pujals AM, Gibson J, et al. Dissection of major depressive disorder using polygenic risk scores for schizophrenia in two independent cohorts. Transl Psychiatry. 2016; 6(11):e938.

35.Xavier RM, Dungan JR, Keefe RSE, Vorderstrasse A. Polygenic signal for symptom dimensions and cognitive performance in patients with chronic schizophrenia. Schizophr Res Cogn. 2018; 12: 11–19.

36.Benca CE, Derringer JL, Corley RP, Young SE, Keller MC, Hewitt JK, et al. Predicting Cognitive Executive Functioning with Polygenic Risk Scores for Psychiatric Disorders. Behav Genet. 2017; 47(1): 11–24.

37.Córdova-Palomera A, Kaufmann T, Bettella F, Wang Y, Doan NT, van der Meer D, et al. Effects of autozygosity and schizophrenia polygenic risk on cognitive and brain developmental trajectories. Eur J Hum Genet EJHG. 2018; 26(7): 1049–1059.

38.Germine L, Robinson EB, Smoller JW, Calkins ME, Moore TM, Hakonarson H, et al. Association between polygenic risk for schizophrenia, neurocognition and social cognition across development. Transl Psychiatry. 2016; 6(10):e924.

39.Hagenaars SP, Harris SE, Davies G, Hill WD, Liewald DCM, Ritchie SJ, et al. Shared genetic aetiology between cognitive functions and physical and mental health in UK Biobank (N = 112 151) and 24 GWAS consortia. Mol Psychiatry. 2016; 21(11): 1624–1632.

40.Hatzimanolis A, Bhatnagar P, Moes A, Wang R, Roussos P, Bitsios P, et al. Common genetic variation and schizophrenia polygenic risk influence neurocognitive performance in young adulthood. Am J Med Genet Part B. 2015; 168B(5): 392–401.

41.Krapohl E, Euesden J, Zabaneh D, Pingault J-B, Rimfeld K, von Stumm S, et al. Phenome-wide analysis of genome-wide polygenic scores. Mol Psychiatry. 2016; 21(9): 1188–1193.

42.Lencz T, Knowles E, Davies G, Guha S, Liewald DC, Starr JM, et al. Molecular genetic evidence for overlap between general cognitive ability and risk for schizophrenia: a report from the Cognitive Genomics consorTium (COGENT). Mol Psychiatry. 2014; 19(2): 168–174.

43.Liebers DT, Pirooznia M, Seiffudin F, Musliner KL, Zandi PP, Goes FS. Polygenic Risk of Schizophrenia and Cognition in a Population-Based Survey of Older Adults. Schizophr Bull. 2016; 42(4): 984–991.

44.McIntosh AM, Gow A, Luciano M, Davies G, Liewald DC, Harris SE, et al. Polygenic risk for schizophrenia is associated with cognitive change between childhood and old age. Biol Psychiatry. 2013; 73(10): 938–943.

45.Rampino A, Taurisano P, Fanelli G, Attrotto M, Torretta S, Antonucci LA, et al. A Polygenic Risk Score of glutamatergic SNPs associated with schizophrenia predicts attentional behavior and related brain activity in healthy humans. Eur Neuropsychopharmacol J Eur Coll Neuropsychopharmacol. 2017; 27(9): 928–939.

46.Riglin L, Collishaw S, Richards A, Thapar AK, Maughan B, O’Donovan MC, et al. Schizophrenia risk alleles and neurodevelopmental outcomes in childhood: a population-based cohort study. Lancet Psychiatry. 2017; 4(1): 57–62.

47.Power RA, Steinberg S, Bjornsdottir G, Rietveld CA, Abdellaoui A, Nivard MM, et al. Polygenic risk scores for schizophrenia and bipolar disorder predict creativity. Nat Neurosci. 2015; 18(7): 953–955.

48.Hill WD, Marioni RE, Maghzian O, Ritchie SJ, Hagenaars SP, McIntosh AM, et al. A combined analysis of genetically correlated traits identifies 187 loci and a role for neurogenesis and myelination in intelligence. Mol Psychiatry. 2018 Jan 11; doi: 10.1038/s41380-017-0001-5.

49.Sørensen HJ, Debost J-C, Agerbo E, Benros ME, McGrath JJ, Mortensen PB, et al. Polygenic Risk Scores, School Achievement, and Risk for Schizophrenia: A Danish Population-Based Study. Biol Psychiatry. 2018; 84(9): 684–691.

50.Hill WD, Davies G, CHARGE Cognitive Working Group, Liewald DC, McIntosh AM, Deary IJ. Age-Dependent Pleiotropy Between General Cognitive Function and Major Psychiatric Disorders. Biol Psychiatry. 2016; 80(4): 266–273.

51.Brainstorm Consortium, Anttila V, Bulik-Sullivan B, Finucane HK, Walters RK, Bras J, et al. Analysis of shared heritability in common disorders of the brain. Science. 2018; 360(6395). pii: eaap8757. doi: 10.1126/science.aap8757.

52.Stefansson H, Meyer-Lindenberg A, Steinberg S, Magnusdottir B, Morgen K, Arnarsdottir S, et al. CNVs conferring risk of autism or schizophrenia affect cognition in controls. Nature. 2013; 505(7483): 361–366.

53.Dudbridge F. Power and predictive accuracy of polygenic risk scores. PLoS Genet. 2013; 9(3):e1003348.

54.GBD 2016 Disease and Injury Incidence and Prevalence Collaborators. Global, regional, and national incidence, prevalence, and years lived with disability for 328 diseases and injuries for 195 countries, 1990-2016: a systematic analysis for the Global Burden of Disease Study 2016. Lancet. 2017; 390(10100): 1211–1259.

55.Cruz BF, Resende CB de, Carvalhaes CF, Cardoso CS, Teixeira AL, Keefe RS, et al. Interview-based assessment of cognition is a strong predictor of quality of life in patients with schizophrenia and severe negative symptoms. Rev Bras Psiquiatr Sao Paulo Braz 1999. 2016; 38(3): 216–221.

56.Tas C, Brown E, Cubukcuoglu Z, Aydemir O, Danaci AE, Brüne M. Towards an integrative approach to understanding quality of life in schizophrenia: the role of neurocognition, social cognition, and psychopathology. Compr Psychiatry. 2013; 54(3): 262–268.

57.Savilla K, Kettler L, Galletly C. Relationships between cognitive deficits, symptoms and quality of life in schizophrenia. Aust N Z J Psychiatry. 2008; 42(6): 496–504.

引用本文

Sabrina K. Schaupp,Thomas G. Schulze,Monika Budde*. Let’s Talk about the Association between Schizophrenia Polygenic Risk Scores and Cognition in Patients and the General Population: A Review, Journal of Psychiatry and Brain Science. 2018; 3; (6). https://doi.org/10.20900/jpbs.20180012.

文献评论

相关学者

相关机构