Endophenotype Potential of Nucleus Accumbens Functional Connectivity: Effects of Polygenic Risk for Schizophrenia Interacting with Childhood Adversity-Journal of Psychiatry and Brain Science-CSCIED科技核心评价数据库-手机版

Endophenotype Potential of Nucleus Accumbens Functional Connectivity: Effects of Polygenic Risk for Schizophrenia Interacting with Childhood Adversity

Endophenotype Potential of Nucleus Accumbens Functional Connectivity: Effects of Polygenic Risk for Schizophrenia Interacting with Childhood Adversity

ES评分 0 浏览量：765 下载量：0

全文阅读下载引用收藏

DOI	10.20900/jpbs.20190011
刊名	Journal of Psychiatry and Brain Science JPBS
年，卷(期)	2019, 4(4)
作者	Christopher Eberle,Yorick Peterse,Filip Jukic,Bertram Müller-Myhsok,Darina Czamara,Jade Martins,Vanessa Schmoll,Michael Czisch,Elisabeth B. Binder,Philipp G. Sämann*,
作者单位	1 Max Planck Institute of Psychiatry, 80804 Munich, Germany; 2 Department of Translational Research in Psychiatry, Max Planck Institute of Psychiatry, 80804 Munich, Germany; 3 Institute of Translational Medicine, University of Liverpool, United Kingdom
Abstract	Epidemiological and genetic studies suggest that schizophrenia (SCZ) is associated with both polygenic and environmental risk factors. Little is known if these factors project on common functional circuits relevant to the pathophysiology of SCZ. Here we focussed on resting state functional MRI (rsfMRI) as a biological measure to investigate if genetic and environmental factors for SCZ risk affect the same circuits in healthy controls as well as patients. For this, we compared the effects of a polygenic risk score for SCZ (PGRS), childhood adversity (CA) and their interaction on functional connectivity density (FCD) mapping and nucleus accumbens (NAcc) seed connectivity between 23 patients with SCZ or schizoaffective disorder and 253 healthy subjects. Patients demonstrated strong FCD increases compared with healthy controls mainly in subcortical nuclei including the NAcc, replicating previous reports. In healthy subjects, FCD of the NAcc was positively correlated with both the PGRS and the PGRS-CA-interaction. Both for high PGRS and PGRS-CA-interaction, fine-mapping revealed higher connectivity between the NAcc and visual association cortices. In conclusion, polygenic risk for SCZ shifted global and regionally specific connectivity of the NAcc in healthy subjects into the direction of the connectivity pattern observed in SCZ, and this shift was intensified by higher levels of CA.
KeyWord	schizophrenia; childhood adversity; polygenic risk score; functional MRI; resting state; functional connectivity density; nucleus accumbens
基金项目
页码	-

参考文献
相关文献

1.Tandon R, Nasrallah HA, Keshavan MS. Schizophrenia, ‘Just the Facts’ 4. Clinical Features and Conceptualization. Schizophr Res. 2009;110(1-3):1-23.

2.Zubin J, Spring B. Vulnerability: A New View of Schizophrenia. J Abnorm Psychol. 1977;86(2):103-26.

3.Sullivan PF, Kendler KS, Neale MC. Schizophrenia as a Complex Trait. Arch Gen Psychiatry. 2003;60(12):1187.

4.Freedman R, Leonard S, Olincy A, Kaufmann CA, Malaspina D, Cloninger CR, et al. Evidence for the Multigenic Inheritance of Schizophrenia. Am J Med Genet. 2001;105(8):794-800.

5.Lichtenstein P, Björk C, Hultman CM, Scolnick E, Sklar P, Sullivan PF. Recurrence Risks for Schizophrenia in a Swedish National Cohort. Psychol Med. 2006;36(10):1417-25.

6.Schizophrenia Working Group of the Psychiatric Genomics Consortium. Biological Insights from 108 Schizophrenia-Associated Genetic Loci. Nature. 2014;511(7510):421-7.

7.Purcell SM, Moran JL, Fromer M, Ruderfer D, Solovieff N, Roussos P, et al. A Polygenic Burden of Rare Disruptive Mutations in Schizophrenia. Nature. 2014;506(7487):185-90.

8.54van Os J, Kenis G, Rutten BPF. The Environment and Schizophrenia. Nature. 2010;468(7321):203-12.

9.Weinberger DR. Implications of Normal Brain Development for the Pathogenesis of Schizophrenia. Arch Gen Psychiatry. 1987;44(7):660-9.

10.Bentall RP, Wickham S, Shevlin M, Varese F. Do Specific Early-Life Adversities Lead to Specific Symptoms of Psychosis? A Study from the 2007 the Adult Psychiatric Morbidity Survey. Schizophr Bull. 2012;38(4):734-40.

11.Bentall RP, Fernyhough C. Social Predictors of Psychotic Experiences: Specificity and Psychological Mechanisms. Schizophr Bull. 2008;34(6):1012-20.

12.Read J, van Os J, Morrison AP, Ross CA. Childhood Trauma, Psychosis and Schizophrenia: A Literature Review with Theoretical and Clinical Implications. Acta Psychiatr Scand. 2005;112(5):330-50.

13.Thompson PM, Vidal C, Giedd JN, Gochman P, Blumenthal J, Nicolson R, et al. Mapping Adolescent Brain Change Reveals Dynamic Wave of Accelerated Gray Matter Loss in Very Early-Onset Schizophrenia. Proc Natl Acad Sci U S A. 2001;98(20):11650-5.

14.18van Erp TGM, Hibar DP, Rasmussen JM, Glahn DC, Pearlson GD, Andreassen OA, Agartz I, et al. Subcortical Brain Volume Abnormalities in 2028 Individuals with Schizophrenia and 2540 Healthy Controls via the ENIGMA Consortium. Mol Psychiatry. 2016;21(4):585.

15.Berger GE, Cali F, Bartholomeusz SJ, Wood AA, Phillips LJ, Proffitt T, et al. Ventricular Volumes across Stages of Schizophrenia and Other Psychoses. Aust N Z J Psychiatry. 2017;51(10):1041-51.

16.Olabi B, Ellison-Wright I, McIntosh AM, Wood SJ, Bullmore E, Lawrie SM. Are There Progressive Brain Changes in Schizophrenia? A Meta-Analysis of Structural Magnetic Resonance Imaging Studies. Biol Psychiatry. 2011;70(1):88-96.

17.27van den Heuvel MP, Hulshoff Pol HE. Exploring the Brain Network: A Review on Resting-State fMRI Functional Connectivity. Eur Neuropsychopharmacol. 2010;20(8):519-34. doi: 10.1016/j.euroneuro.2010.03.008

18.Mwansisya TE, Hu A, Li Y, Chen X, Wu G, Huang X, et al. Task and Resting-State fMRI Studies in First-Episode Schizophrenia: A Systematic Review. Schizophr Res. 2017;189:9-18.

19.Kiparizoska S, Ikuta T. Disrupted Olfactory Integration in Schizophrenia: Functional Connectivity Study. Int J Neuropsychopharmacol. 2017;20(9):740-6.

20.Lee KL, Oh H, Suh JH, Cho KIK, Yoon YB, Shin W-G, et al. Functional and Structural Connectivity of the Cerebellar Nuclei With the Striatum and Cerebral Cortex in First-Episode Psychosis. J Neuropsychiatry Clin Neurosci. 2019;31(2):143-51. doi: 10.1176/appi.neuropsych.17110276

21.Liu C, Zhang W, Chen G, Tian H, Li J, Qu H, et al. Aberrant Patterns of Local and Long-Range Functional Connectivity Densities in Schizophrenia. Oncotarget. 2017;8(29):48196-203.

22.Zhuo C, Zhu J, Qin W, Qu H, Ma X, Tian H, et al. Functional Connectivity Density Alterations in Schizophrenia. Front Behav Neurosci. 2014;8:404. doi: 10.3389/fnbeh.2014.00404

23.Grace AA. Gating of Information Flow within the Limbic System and the Pathophysiology of Schizophrenia. Brain Res Brain Res Rev. 2000;31(2-3):330-41.

24.Groenewegen HJ, Trimble M. The Ventral Striatum as an Interface between the Limbic and Motor Systems. CNS Spectr. 2007;12(12):887-92.

25.Howes OD, Kapur S. The Dopamine Hypothesis of Schizophrenia: Version III—the Final Common Pathway. Schizophr Bull. 2009;35(3):549-62.

26.Okubo Y, Suhara T, Suzuki K, Kobayashi K, Inoue O, Terasaki O, et al. Decreased Prefrontal Dopamine D1 Receptors in Schizophrenia Revealed by PET. Nature. 1997;385(6617):634-6.

27.Knutson B, Sasha EB, Gibbs SE. Linking Nucleus Accumbens Dopamine and Blood Oxygenation. Psychopharmacology. 2007;191(3):813-22.

28.Rolland B, Amad A, Poulet E, Bordet R, Vignaud A, Bation R, et al. Resting-State Functional Connectivity of the Nucleus Accumbens in Auditory and Visual Hallucinations in Schizophrenia. Schizophr Bull. 2015;41(1):291-9.

29.O’Donnell P, Grace AA. Different Effects of Subchronic Clozapine and Haloperidol on Dye-Coupling between Neurons in the Rat Striatal Complex. Neuroscience. 1995;66(4):763-7.

30.Achterberg M, Bakermans-Kranenburg MJ, van Ijzendoorn MH, van der Meulen M, Tottenham N, Crone EA. Distinctive Heritability Patterns of Subcortical-Prefrontal Cortex Resting State Connectivity in Childhood: A Twin Study. NeuroImage. 2018;175:138-49.

31.Gottesman II, Gould TD. The Endophenotype Concept in Psychiatry: Etymology and Strategic Intentions. Am J Psychiatry. 2003;160(4):636-45.

32.Dezhina Z, Ranlund S, Kyriakopoulos M, Williams SCR, Dima D. A Systematic Review of Associations between Functional MRI Activity and Polygenic Risk for Schizophrenia and Bipolar Disorder. Brain Imaging Behav. 2019;13(3): 862-77. doi: 10.1007/s11682-018-9879-z

33.Lancaster TM, Ihssen N, Brindley LM, Tansey KE, Mantripragada K, O’Donovan MC, et al. Associations between Polygenic Risk for Schizophrenia and Brain Function during Probabilistic Learning in Healthy Individuals. Human Brain Mapp. 2016;37(2):491-500.

34.Lancaster TM, Dimitriadis SL, Tansey KE, Perry G, Ihssen N, Jones DK, et al. Structural and Functional Neuroimaging of Polygenic Risk for Schizophrenia: A Recall-by-Genotype–Based Approach. Schizophr Bull. 2019;45(2):405-14. doi: 10.1093/schbul/sby037

35.Lancaster TM, Linden DE, Tansey KE, Banaschewski T, Bokde AL, Bromberg U, et al. Polygenic Risk of Psychosis and Ventral Striatal Activation During Reward Processing in Healthy Adolescents. JAMA Psychiatry. 2016;73(8): 852-61.

36.Wang T, Zhang X, Li A, Zhu M, Liu S, Qin W, et al. Polygenic Risk for Five Psychiatric Disorders and Cross-Disorder and Disorder-Specific Neural Connectivity in Two Independent Populations. Neuroimage Clin. 2017;14:441-9.

37.Hoffmann C, Van Rheenen TE, Mancuso SG, Zalesky A, Bruggemann J, Lenroot RK, et al. Exploring the Moderating Effects of Dopaminergic Polymorphisms and Childhood Adversity on Brain Morphology in Schizophrenia-Spectrum Disorders. Psychiatry Res Neuroimaging. 2018;281:61-8.

38.Cancel A, Dallel S, Zine A, El-Hage W, Fakra E. Understanding the Link between Childhood Trauma and Schizophrenia: A Systematic Review of Neuroimaging Studies. Neurosci Biobehav Rev. 2019. doi: 10.1016/j.neubiorev.2019.05.024

39.Kaiser RH, Clegg R, Goer F, Pechtel P, Beltzer M, Vitaliano G, et al. Childhood Stress, Grown-up Brain Networks: Corticolimbic Correlates of Threat-Related Early Life Stress and Adult Stress Response. Psychol Med. 2018;48(7):1157-66.

40.Marusak HA, Hatfield JRB, Thomason ME, Rabinak CA. Reduced Ventral Tegmental Area-Hippocampal Connectivity in Children and Adolescents Exposed to Early Threat. Biol Psychiatry Cogn Neurosci Neuroimaging. 2017;2(2):130-7.

41.Kaag AM, Reneman L, Homberg J, van den Brink W, van Wingen GA. Enhanced Amygdala-Striatal Functional Connectivity during the Processing of Cocaine Cues in Male Cocaine Users with a History of Childhood Trauma. Front Psychiatry. 2018;9:70.

42.Tomasi D, Volkow ND. Functional Connectivity Density Mapping. Proc Natl Acad Sci U S A. 2010;107(21):9885-90.

43.Tomasi D, Volkow ND. Association between Functional Connectivity Hubs and Brain Networks. Cereb Cortex. 2011;21(9):2003-13.

44.Tomasi D, Volkow ND. Functional Connectivity Hubs in the Human Brain. NeuroImage. 2011;57(3):908-17.

45.Budde M, Anderson-Schmidt H, Gade K, Reich-Erkelenz D, Adorjan K, Kalman JL, et al. A longitudinal approach to biological psychiatric research: The PsyCourse study. Am J Med Genet B Neuropsychiatr Genet. 2019 Mar;180(2):89-102. doi: 10.1002/ajmg.b.32639

46.Bernstein DP, Fink L. Childhood Trauma Questionnaire: A Retrospective Self-Report: Manual. Orlando (US): Psychological Corporation; 1998.

47.Wingenfeld K, Spitzer C, Mensebach C, Grabe HJ, Hill A, Gast U, et al.
[The German Version of the Childhood Trauma Questionnaire (CTQ): Preliminary Psychometric Properties.]. Psychother Psychosom Med Psychol. 2010;60(11):442-50. doi: 10.1055/s-0030-1247564. German

48.Bernstein DP, Stein JA, Newcomb MD, Walker E, Pogge D, Ahluvalia T, et al. Development and Validation of a Brief Screening Version of the Childhood Trauma Questionnaire. Child Abuse Neglect. 2003;27(2):169-90.

49Häuser W, Schmutzer G, Brähler E, Glaesmer H. Maltreatment in Childhood and Adolescence: Results from a Survey of a Representative Sample of the German Population. Dtsch Arztebl Int. 2011;108(17):287-94. doi: 10.3238/arztebl.2011.0287

50.Kay SR, Fiszbein A, Opler LA. The Positive and Negative Syndrome Scale (PANSS) for Schizophrenia. Schizophr Bull. 1987;13(2):261-76.

51.Ashburner J. A Fast Diffeomorphic Image Registration Algorithm. NeuroImage. 2007;38(1):95-113.

52.Barnes J. Visual Hallucinations in Parkinson’s Disease: A Review and Phenomenological Survey. J Neurol Neurosurg Psychiatry. 2001;70(6):727-33.

53.Shaun P, Neale B, Todd-Brown K, Thomas L, Ferreira MAR, Bender D, et al. PLINK: A Tool Set for Whole-Genome Association and Population-Based Linkage Analyses. Am J Human Genet. 2007;81(3):559-75.

54.Delaneau O, Marchini J, Zagury J-F. A Linear Complexity Phasing Method for Thousands of Genomes. Nature Methods. 2011;9(2):179-81.

55.Howie BN, Donnelly P, Marchini J. A Flexible and Accurate Genotype Imputation Method for the Next Generation of Genome-Wide Association Studies. PLoS Genet. 2009;5(6):e1000529.

56.Power JD, Barnes KA, Snyder AZ, Schlaggar BL, Petersen SE. Spurious but Systematic Correlations in Functional Connectivity MRI Networks Arise from Subject Motion. NeuroImage. 2012;59(3):2142-54.

57.Behzadi Y, Restom K, Liau J, Liu TT. A Component Based Noise Correction Method (CompCor) for BOLD and Perfusion Based fMRI. NeuroImage. 2007;37(1):90-101.

58.Elbau, IG, Brücklmeier B, Uhr M, Arloth J, Czamara D, Spoormaker VI, et al. The Brain’s Hemodynamic Response Function Rapidly Changes under Acute Psychosocial Stress in Association with Genetic and Endocrine Stress Response Markers. Proc Natl Acad Sci U S A. 2018;115(43): E10206-15.

59.Sämann PG, Wehrle R, Hoehn D, Spoormaker VI, Peters H, Tully C, Holsboer F, Czisch M. Development of the brain's default mode network from wakefulness to slow wave sleep. Cereb Cortex. 2011 Sep;21(9):2082-93. doi: 10.1093/cercor/bhq295

60.Friston KJ, Penny WD, Glaser DF. Conjunction Revisited. NeuroImage. 2005;25(3):661-7.

61.Lee MH, Smyser CD, Shimony JS. Resting-State fMRI: A Review of Methods and Clinical Applications. AJNR. Am J Neuroradiol. 2012;34(10):1866-72.

62.Cole MW, Pathak S, Schneider W. Identifying the Brain’s Most Globally Connected Regions. NeuroImage. 2010;49(4):3132-48.

63.Zhuo C, Zhu J, Wang C, Qu H, Ma X, Tian H, et al. Brain Structural and Functional Dissociated Patterns in Schizophrenia. BMC Psychiatry. 2017;17(1):45.

64.Lin P, Wang X, Zhang B, Kirkpatrick B, Öngür D, Levitt JJ, Jovicich J, Yao S, Wang X. Functional dysconnectivity of the limbic loop of frontostriatal circuits in first-episode, treatment-naive schizophrenia. Hum Brain Mapp. 2018 Feb;39(2):747-757. doi: 10.1002/hbm.23879

65.Wang X, Zhang Y, Long Z, Zheng J, Zhang Y, Han S, et al. Frequency-Specific Alteration of Functional Connectivity Density in Antipsychotic-Naive Adolescents with Early-Onset Schizophrenia. J Psychiatr Res. 2017;95:68-75.

66.Chen J, Rashid B, Yu Q, Liu J, Lin D, Du Y, et al. Variability in Resting State Network and Functional Network Connectivity Associated With Schizophrenia Genetic Risk: A Pilot Study. Front Neurosci. 2018;12:114.

67.Crisafulli C, Drago A, Calabrò M, Spina E, Serretti A. A Molecular Pathway Analysis Informs the Genetic Background at Risk for Schizophrenia. Prog Neuro-Psychopharmacol Biol Psychiatry. 2015;59(June):21-30.

68.Milner AD. How Do the Two Visual Streams Interact with Each Other? Exp Brain Res. 2017;235(5):1297-308.

69.Morrison AP, Petersen T. Trauma, Metacognition And Predisposition To Hallucinations In Non-Patients. Behav Cogn Psychother. 2003;31(3):235-46.

70.Mitchell SJ, Maguire EP, Cunningham L, Gunn BG, Linke M, Zechner U, et al. Early-Life Adversity Selectively Impairs α2-GABAA Receptor Expression in the Mouse Nucleus Accumbens and Influences the Behavioral Effects of Cocaine. Neuropharmacology. 2018;141:98-112. doi: 10.1016/j.neuropharm.2018.08.021

71.Manza P, Tomasi D, Volkow ND. Subcortical Local Functional Hyperconnectivity in Cannabis Dependence. Biol Psychiatry Cogn Neurosci Neuroimaging. 2018;3(3):285-93.

72.Bersani G, Orlandi V, Kotzalidis GD, Pancheri P. Cannabis and Schizophrenia: Impact on Onset, Course, Psychopathology and Outcomes. Eur Arch Psychiatry Clin Neurosci. 2002;252(2):86-92.

73.Gag, SH, Zammit S, Hickman M. Stronger Evidence Is Needed before Accepting That Cannabis Plays an Important Role in the Aetiology of Schizophrenia in the Population. F1000 Med Rep. 2013;5:2. doi: 10.3410/M5-2

74.Moore THM, Zammit S, Lingford-Hughes A, Barnes TRE, Jones PB, Burke M, et al. Cannabis Use and Risk of Psychotic or Affective Mental Health Outcomes: A Systematic Review. Lancet. 2007;370(9584):319-28.

75.Fischer AS, Whitfield-Gabrieli S, Roth RM, Brunette MR, Green AI. Impaired Functional Connectivity of Brain Reward Circuitry in Patients with Schizophrenia and Cannabis Use Disorder: Effects of Cannabis and THC. Schizop Res. 2014;158(1-3):176-82.

76.Lenzenweger MF. Schizotypy, Schizotypic Psychopathology and Schizophrenia. World Psychiatry. 2018; 17(1):25-6.

77.Samanez-Larkin GR, Gibbs SEB, Khanna K, Nielsen L, Carstensen LL, Knutson B. Anticipation of Monetary Gain but Not Loss in Healthy Older Adults. Nature Neurosci. 2007;10(6):787-91.

78.Viswanathan V, Lee S, Gilman JM, Kim BW, Lee N, Chamberlain L, et al. Age-Related Striatal BOLD Changes without Changes in Behavioral Loss Aversion. Front Human Neurosci. 2015;9:176. doi: 10.3389/fnhum.2015.00176

引用本文

Christopher Eberle,Yorick Peterse,Filip Jukic,Bertram Müller-Myhsok,Darina Czamara,Jade Martins,Vanessa Schmoll,Michael Czisch,Elisabeth B. Binder,Philipp G. Sämann*. Endophenotype Potential of Nucleus Accumbens Functional Connectivity: Effects of Polygenic Risk for Schizophrenia Interacting with Childhood Adversity, Journal of Psychiatry and Brain Science. 2019; 4; (4). https://doi.org/10.20900/jpbs.20190011.

文献评论

相关学者

相关机构