Why Naked Mole-Rats Have High Oxidative Damage but Live a Long Life: A Simple Explanation Based on the Oxidative Stress Theory of Aging-Advances in Geriatric Medicine and Research-CSCIED科技核心评价数据库-手机版

Why Naked Mole-Rats Have High Oxidative Damage but Live a Long Life: A Simple Explanation Based on the Oxidative Stress Theory of Aging

Why Naked Mole-Rats Have High Oxidative Damage but Live a Long Life: A Simple Explanation Based on the Oxidative Stress Theory of Aging

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DOI	10.20900/agmr20200006
刊名	Advances in Geriatric Medicine and Research AGMR
年，卷(期)	2020, 2(1)
作者	Wenyun Zuo,Xiaolong Tang,Chen Hou*,
作者单位	Department of Biology, Stanford University, Stanford, CA 94305, USA ; Institute of Biochemistry and Molecular Biology, School of Life Sciences, Lanzhou University, Lanzhou, 730000, China ; Department of Biological Sciences, Missouri University of Science and Technology, Rolla, MO 65409, USA ;
Abstract	Compared to mice with the same body mass, naked mole-rats have a lower metabolic rate, higher homeostasis-maintaining activities, higher oxidative damage levels, but a longer lifespan. These observations have raised serious challenges to the widely accepted oxidative stress theory of aging, which suggests a negative correlation between damage levels and lifespan. Here, we introduce a simple theoretical model based on energy conservation and the oxidative stress theory. Employing the model and the physiological parameters of mice and naked mole-rats, we explain why naked mole-rats have higher damage levels despite their higher somatic maintenance efforts; why damage levels in naked mole-rats seem not to change over age; and how these factors concertedly result in a longer lifespan in naked mole-rats. Our results highlight the energy tradeoff between biosynthesis and somatic maintenance, and suggest that the rate of damage accumulation over age and the existence of a threshold of damage for death are the keys to solve the paradox raised by naked mole-rats.
KeyWord	energy tradeoff; biosynthesis; proteostasis; comparative study
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Wenyun Zuo,Xiaolong Tang,Chen Hou*. Why Naked Mole-Rats Have High Oxidative Damage but Live a Long Life: A Simple Explanation Based on the Oxidative Stress Theory of Aging, Advances in Geriatric Medicine and Research. 2020; 2; (1). https://doi.org/10.20900/agmr20200006.

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