Grant Report on the Effects of Childhood Maltreatment on Neurocircuitry in Adolescent Depression-Journal of Psychiatry and Brain Science-CSCIED科技核心评价数据库-手机版

Grant Report on the Effects of Childhood Maltreatment on Neurocircuitry in Adolescent Depression

Grant Report on the Effects of Childhood Maltreatment on Neurocircuitry in Adolescent Depression

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DOI	10.20900/jpbs.20200016
刊名	Journal of Psychiatry and Brain Science JPBS
年，卷(期)	2020, 5(4)
作者	Marie L. Gillespie,Uma Rao*,
作者单位	Department of Psychiatry & Human Behavior, School of Medicine, University of California, Irvine, 5251 California Ave., Suite 240, Irvine, CA 92617, USA ; 1Department of Psychiatry & Human Behavior, School of Medicine, University of California, Irvine, 5251 California Ave., Suite 240, Irvine, CA 92617, USA ;
Abstract	This report describes the protocol for an ongoing project funded by the National Institutes of Health (R01MH108155) that is focused on effects of childhood maltreatment (MALTX) on neurocircuitry changes associated with adolescent major depressive disorder (MDD). Extant clinical and neuroimaging literature on MDD is reviewed, which has relied on heterogeneous samples that do not parse out the unique contribution of MALTX on neurobiological changes in MDD. Employing a 2 × 2 study design (controls with no MALTX or MDD, MALTX only, MDD only, and MDD + MALTX), and based on a cohesive theoretical model that incorporates behavioral, cognitive and neurobiological domains, we describe the multi-modal neuroimaging techniques used to test whether structural and functional alterations in the fronto-limbic and fronto-striatal circuits associated with adolescent MDD are moderated by MALTX. We hypothesize that MDD + MALTX youth will show alterations in the fronto-limbic circuit, with reduced connectivity between the amygdala (AMG) and the prefrontal cortex (PFC), as the AMG is sensitive to stress/threat during development. Participants with MDD will exhibit increased functional connectivity between the AMG and PFC due to self-referential negative emotions. Lastly, MDD + MALTX will only show changes in motivational/anticipatory aspects of the fronto-striatal circuit, and MDD will exhibit changes in motivational and consummatory/outcome aspects of reward-processing. Our goal is to identify distinct neural substrates associated with MDD due to MALTX compared to other causes, as these markers could be used to more effectively predict treatment outcome, index treatment response, and facilitate alternative treatments for adolescents who do not respond well to traditional approaches.
KeyWord	adolescence; maltreatment; depression; neurocircuitry; fronto-limbic; front-striatal; functional connectivity
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Marie L. Gillespie,Uma Rao*. Grant Report on the Effects of Childhood Maltreatment on Neurocircuitry in Adolescent Depression, Journal of Psychiatry and Brain Science. 2020; 5; (4). https://doi.org/10.20900/jpbs.20200016.

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