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Organelle-Specific Autophagy in Cellular Aging and Rejuvenation

Organelle-Specific Autophagy in Cellular Aging and Rejuvenation

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DOI	10.20900/agmr20210010
刊名	Advances in Geriatric Medicine and Research AGMR
年，卷(期)	2021, 3(2)
作者	Tyler J. Butsch,Bhaswati Ghosh,K. Adam Bohnert*,
作者单位	These authors contributed equally to this work. ; Department of Biological Sciences, Louisiana State University, 220 Life Sciences Building, Baton Rouge, LA 70803, USA ;
Abstract	The health of a cell requires proper functioning, regulation, and quality control of its organelles, the membrane-enclosed compartments inside the cell that carry out its essential biochemical tasks. Aging commonly perturbs organelle homeostasis, causing problems to cellular health that can spur the initiation and progression of degenerative diseases and related pathologies. Here, we discuss emerging evidence indicating that age-related defects in organelle homeostasis stem in part from dysfunction of the autophagy-lysosome system, a pivotal player in cellular quality control and damage clearance. We also highlight natural examples from biology where enhanced activity of the autophagy-lysosome system might be harnessed to erase age-related organelle damage, raising potential implications for cellular rejuvenation.
KeyWord	cell biology; autophagy; organelles; aging; rejuvenation
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Tyler J. Butsch,Bhaswati Ghosh,K. Adam Bohnert*. Organelle-Specific Autophagy in Cellular Aging and Rejuvenation, Advances in Geriatric Medicine and Research. 2021; 3; (2). https://doi.org/10.20900/agmr20210010.

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