Obesity, Vascular Disease and Frailty in Aging Women with HIV-Advances in Geriatric Medicine and Research-CSCIED科技核心评价数据库-手机版

Obesity, Vascular Disease and Frailty in Aging Women with HIV

Obesity, Vascular Disease and Frailty in Aging Women with HIV

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DOI	10.20900/agmr20210014
刊名	Advances in Geriatric Medicine and Research AGMR
年，卷(期)	2021, 3(3)
作者	Deborah R. Gustafson*,Samy I. McFarlane,
作者单位	Section for NeuroEpidemiology, Department of Neurology, State University of New York Downstate Health Sciences University, Brooklyn, New York, NY 11203, USA ; University of Skövde, 541 28 Skövde, Sweden ;
Abstract	Women with chronic HIV infection (WWH) living in the United States, experience a disproportionately high rate of obesity compared to uninfected populations. Both overweight and obesity, particularly central obesity, are major contributors to insulin resistance, hypertension, and dyslipidemia—the major components of metabolic syndromes, including type 2 diabetes, and leading to increased cardiovascular risk, including coronary heart disease, and cerebrovascular diseases. Notably, declining physical performance and frailty co-occur with vascular morbidities as well as changes in bone. These factors tend to exacerbate each other and accelerate the aging trajectory, leading to poorer quality of life, cognitive impairments, dementia, and eventually, death. In WWH, persistent HIV infection, sustained treatment for HIV infection, and concomitant obesity, may accelerate aging-related morbidities and poorer aging outcomes. Furthermore, health disparities factors common among some WWH, are independently associated with obesity and higher vascular risk. The purpose of this review is to describe the constellation of obesity, cardio- and cerebrovascular diseases, bone health and frailty among aging WWH, a 21st century emergence.
KeyWord	frailty; HIV; obesity; cardiovascular disease; aging; bone
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Deborah R. Gustafson*,Samy I. McFarlane. Obesity, Vascular Disease and Frailty in Aging Women with HIV, Advances in Geriatric Medicine and Research. 2021; 3; (3). https://doi.org/10.20900/agmr20210014.

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