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Dysregulated Purine Metabolism Contributes to Age-Associated Lower Urinary Tract Dysfunctions

Dysregulated Purine Metabolism Contributes to Age-Associated Lower Urinary Tract Dysfunctions

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DOI	10.20900/agmr20210018
刊名	Advances in Geriatric Medicine and Research AGMR
年，卷(期)	2021, 3(4)
作者	Lori A. Birder*,Edwin K. Jackson,
作者单位	Renal-Electrolyte Division, Department of Medicine, University of Pittsburgh School of Medicine, Pittsburgh PA 15261, USA ; Department of Pharmacology and Chemical Biology, University of Pittsburgh School of Medicine, Pittsburgh PA 15261, USA ;
Abstract	Lower urinary tract (LUT) dysfunction is common in the older adult. Aging is associated with a number of both storage and voiding problems which are classified into syndromes with overlapping symptoms. Despite the prevalence and consequences of these syndromes, LUT disorders continue to be undertreated as few therapeutic options exist. Here, we propose that dysregulated metabolism of purine nucleotides results in an accumulation of uro-damaging hypoxanthine (a source of reactive oxygen species or ROS), which provides a mechanism for defects in sensory signaling and contractility, culminating in abnormal urodynamic behavior.
KeyWord	purine nucleoside phosphorylase; 8-aminoguanine; lower urinary tract; aging
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引用本文

Lori A. Birder*,Edwin K. Jackson. Dysregulated Purine Metabolism Contributes to Age-Associated Lower Urinary Tract Dysfunctions, Advances in Geriatric Medicine and Research. 2021; 3; (4). https://doi.org/10.20900/agmr20210018.

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