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Aging Diminishes Mucociliary Clearance of the Lung

Aging Diminishes Mucociliary Clearance of the Lung

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DOI	10.20900/agmr20220005
刊名	Advances in Geriatric Medicine and Research AGMR
年，卷(期)	2022, 4(2)
作者	Kristina L. Bailey*,
作者单位	Research Service, VA Nebraska-Western Iowa Health Care System, Omaha, NE 68105, USA ;
Abstract	Healthy aging leads to a decrease in mucociliary clearance of the lung. Mucociliary clearance is an essential innate immune defense to protect against inhaled particles and microbes. Mucociliary clearance can be affected by changes in cilia function as well as mucus quantity and qualities. With aging, cilia beat frequency slows and there are changes to the characteristics of mucus. These decreases in mucociliary clearance may lead to lung infection such as pneumonia or airway diseases such as bronchiectasis or Chronic Obstructive Pulmonary Diseases.
KeyWord	elderly; pneumonia; bronchiectasis; COPD; senescence; cilia; mucus
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Kristina L. Bailey*. Aging Diminishes Mucociliary Clearance of the Lung, Advances in Geriatric Medicine and Research. 2022; 4; (2). https://doi.org/10.20900/agmr20220005.

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