Aging, Cutaneous Burn Injury and Multi-Organ Complications: The Role of the Gut-Advances in Geriatric Medicine and Research-CSCIED科技核心评价数据库-手机版

Aging, Cutaneous Burn Injury and Multi-Organ Complications: The Role of the Gut

Aging, Cutaneous Burn Injury and Multi-Organ Complications: The Role of the Gut

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DOI	10.20900/agmr20220004
刊名	Advances in Geriatric Medicine and Research AGMR
年，卷(期)	2022, 4(2)
作者	Rachel H. McMahan*,Devin M. Boe,Travis M. Walrath,Juan-Pablo Idrovo,Elizabeth J. Kovacs,
作者单位	Department of Surgery, Division of GI, Trauma and Endocrine Surgery, and Alcohol Research Program, University of Colorado Denver, Anschutz Medical Campus, Aurora, CO 80045, USA ;
Abstract	Advanced age escalates post-burn complications and older burn patients, and even those with relatively minor burns, have worse clinical outcomes after injury. While the mechanism(s) responsible for the compounding effects of age and burn injury have not been defined, in this viewpoint, we highlight the emerging data suggesting that age-mediated impairment of gut barrier integrity and dysbiosis of the fecal microbiome in older subjects may play a role in the heightened multi-organ responses seen in older patients. Studies aimed at exploring the contribution of intestinal dysfunction in age-related exacerbations of post-burn inflammatory responses could highlight novel therapeutic interventions that can be used to treat victims of burns and other traumatic injuries.
KeyWord	advanced age; trauma; intestine; bacteria
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引用本文

Rachel H. McMahan*,Devin M. Boe,Travis M. Walrath,Juan-Pablo Idrovo,Elizabeth J. Kovacs. Aging, Cutaneous Burn Injury and Multi-Organ Complications: The Role of the Gut, Advances in Geriatric Medicine and Research. 2022; 4; (2). https://doi.org/10.20900/agmr20220004.

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