Effects of Low-Volume High-Intensity Interval Training Compared to Moderate-Intensity Continuous Training on Inflammatory Profile in Women with Type 2 Diabetes-Advances in Geriatric Medicine and Research-CSCIED科技核心评价数据库-手机版

Effects of Low-Volume High-Intensity Interval Training Compared to Moderate-Intensity Continuous Training on Inflammatory Profile in Women with Type 2 Diabetes

Effects of Low-Volume High-Intensity Interval Training Compared to Moderate-Intensity Continuous Training on Inflammatory Profile in Women with Type 2 Diabetes

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DOI	10.20900/agmr20220007
刊名	Advances in Geriatric Medicine and Research AGMR
年，卷(期)	2022, 4(3)
作者	Alexis Marcotte-Chénard,Renaud Tremblay,Marie- Michelle Mony,Dominic Tremblay,Pierre Boulay,Martin Brochu,José A. Morais,Isabelle J. Dionne,Marie- France Langlois,Warner Mampuya,Daniel Tessier,Eléonor Riesco*,
作者单位	Faculty of Physical Activity Sciences, University of Sherbrooke, Sherbrooke, QC J1K 2R1, Canada ; Research Centre on Aging, CIUSSS de l’Estrie-CHUS, Sherbrooke, QC J1H 4C4, Canada ; Research Centre of McGill University Health Centre (MUHC) and Division of Geriatric Medicine of MUHC, Montréal, QC H4A 3J1, Canada ; Faculty of Medicine and Health Sciences, University of Sherbrooke, Sherbrooke, QC J1H 5N4, Canada ;
Abstract	Background: The objective was to compare the effects of low-volume high-intensity interval training (HIIT) to moderate-intensity continuous training (MICT) on the inflammatory profile in older women with type 2 diabetes (T2D).Methods: Thirty older physically inactive women (68 ± 5 years) with T2D were randomized in two groups: HIIT (75 min/week with 10 min/session at high intensity) or MICT (150 min/week). Inflammatory profile (IL-6, IL-10, IL-15, TNF-α, and MCP-1; Luminex), body composition (iDXA), and cardiometabolic profile (A1c, glucose, insulin, lipids) were measured in fasting state, before and after the 3-month intervention in 27 participants.Results: While fasting levels of cytokines remained unchanged in the MICT group (p ≥ 0.18), circulating MCP-1 levels increased (from 160.9 [IQR: 133.5–230.2] to 187.88 [155.3–237.3]) in the HIIT group (p = 0.023). Linear regression revealed that changes in MCP-1 concentrations were positively associated with changes in A1c (adjusted R2 = 0.203; p = 0.018). Conclusions: The results of this study suggest that 12 weeks of either low-volume HIIT or MICT do not improve inflammatory markers in older unfit women with T2D. The correlation between changes in A1c and MCP-1 levels support the role of hyperglycemia in low-grade inflammation.
KeyWord	HIIT; MICT; exercise; cytokines
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Alexis Marcotte-Chénard,Renaud Tremblay,Marie- Michelle Mony,Dominic Tremblay,Pierre Boulay,Martin Brochu,José A. Morais,Isabelle J. Dionne,Marie- France Langlois,Warner Mampuya,Daniel Tessier,Eléonor Riesco*. Effects of Low-Volume High-Intensity Interval Training Compared to Moderate-Intensity Continuous Training on Inflammatory Profile in Women with Type 2 Diabetes, Advances in Geriatric Medicine and Research. 2022; 4; (3). https://doi.org/10.20900/agmr20220007.

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