Vagus Nerve Stimulation as a Treatment for Fear and Anxiety in Individuals with Autism Spectrum Disorder-Journal of Psychiatry and Brain Science-CSCIED科技核心评价数据库-手机版

Vagus Nerve Stimulation as a Treatment for Fear and Anxiety in Individuals with Autism Spectrum Disorder

Vagus Nerve Stimulation as a Treatment for Fear and Anxiety in Individuals with Autism Spectrum Disorder

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DOI	10.20900/jpbs.20220007
刊名	Journal of Psychiatry and Brain Science JPBS
年，卷(期)	2022, 7(4)
作者	Tanushree Shivaswamy,Rimenez R. Souza,Crystal T. Engineer,Christa K. McIntyre*,
作者单位	Texas Biomedical Device Center and School of Behavioral and Brain Sciences. The University of Texas at Dallas, 800 West Campbell Road, Richardson, TX 75080, USA ;
Abstract	Anxiety disorders affect a large percentage of individuals who have an autism spectrum disorder (ASD). In children with ASD, excessive anxiety is also linked to gastrointestinal problems, self-injurious behaviors, and depressive symptoms. Exposure-based cognitive behavioral therapies are effective treatments for anxiety disorders in children with ASD, but high relapse rates indicate the need for additional treatment strategies. This perspective discusses evidence from preclinical research, which indicates that vagus nerve stimulation (VNS) paired with exposure to fear-provoking stimuli and situations could offer benefits as an adjuvant treatment for anxiety disorders that coexist with ASD. Vagus nerve stimulation is approved for use in the treatment of epilepsy, depression, and more recently as an adjuvant in rehabilitative training following stroke. In preclinical models, VNS shows promise in simultaneously enhancing consolidation of extinction memories and reducing anxiety. In this review, we will present potential mechanisms by which VNS could treat fear and anxiety in ASD. We also discuss potential uses of VNS to treat depression and epilepsy in the context of ASD, and noninvasive methods to stimulate the vagus nerve.
KeyWord	behavioral therapy; exposure therapy; neurodevelopmental disorders; neuromodulation; rehabilitation
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Tanushree Shivaswamy,Rimenez R. Souza,Crystal T. Engineer,Christa K. McIntyre*. Vagus Nerve Stimulation as a Treatment for Fear and Anxiety in Individuals with Autism Spectrum Disorder, Journal of Psychiatry and Brain Science. 2022; 7; (4). https://doi.org/10.20900/jpbs.20220007.

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