急性冠脉综合征的治疗理念转变——从“易损斑块”到兼顾“易损患者”-国际临床研究杂志-CSCIED科技核心评价数据库-手机版

急性冠脉综合征的治疗理念转变——从“易损斑块”到兼顾“易损患者”

Change of treatment concept of acute coronary syndrome——From "vulnerable plaque" to "vulnerable patients"

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DOI	10.12208/j.ijcr.20220469
刊名	国际临床研究杂志 International Journal of Clinical Research
年，卷(期)	2022, 6(10)
作者	冯雪*,李楠楠,李晓鲁,
作者单位	山东第一医科大学山东济南 ; 山东第一医科大学第一附属医院（山东省千佛山医院）中医眼科山东济南 ; 山东第一医科大学第一附属医院（山东省千佛山医院）急诊医学，山东省医药卫生急救医学重点实验室山东济南 ;
摘要	近年来，心血管疾病成为威胁人类健康的“第一杀手”。我国心血管病患者的负担日渐加重，目前已成为重大公共卫生问题之一，故防治心血管疾病刻不容缓。急性冠脉综合征是目前临床上死亡率、致残率最高的心血管疾病，“易损斑块”及其斑块破裂继发腔内血栓被认为是急性冠状动脉综合征最主要的病理生理学机制。但是，近年来以“易损斑块”为中心的个性化风险评估和诊疗策略并未取得期望的临床实际获益。随着“易损患者”概念的提出，急性冠状动脉综合征的治疗中心从“易损斑块”转变为兼顾“易损患者”，更加强调了把其作为全身性疾病整体性干预的全新理念。本文就此治疗理念的转变作如下综述。
Abstract	In recent years, cardiovascular disease has become the "first killer" threatening human health. The burden of patients with cardiovascular diseases is increasing in China, and it has become one of the major public health problems. Therefore, it is urgent to prevent and treat cardiovascular diseases. Acute coronary syndrome (ACS) is a cardiovascular disease with the highest mortality and disability rate in clinic. Vulnerable plaque and intracavitary thrombus secondary to plaque rupture are considered to be the main pathophysiological mechanism of ACS. However, in recent years, personalized risk assessment and diagnosis and treatment strategies focusing on "vulnerable plaques" have not achieved the desired clinical benefits. With the proposal of the concept of "vulnerable patients", the treatment center of acute coronary syndrome has changed from "vulnerable plaques" to "vulnerable patients", and more emphasis has been placed on the new concept of taking it as a whole intervention for systemic diseases. This article summarizes the transformation of the treatment concept as follows.
关键词	易损斑块；易损患者；急性冠脉综合征；早期预防
KeyWord	Vulnerable plaque; Vulnerable patients; Acute coronary syndrome; early prevention
基金项目
页码	27-31

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引用本文

冯雪*,李楠楠,李晓鲁. 急性冠脉综合征的治疗理念转变——从“易损斑块”到兼顾“易损患者” [J]. 国际临床研究杂志. 2022; 6; (10). 27 - 31.

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