FDI-6下调FoxM1抑制人肝癌细胞增殖迁移-国际临床研究杂志-CSCIED科技核心评价数据库-手机版

FDI-6下调FoxM1抑制人肝癌细胞增殖迁移

FDI-6 down-regulation of FoxM1 inhibits proliferation and migration of human hepatocellular carcinoma cells

ES评分 0 浏览量：724 下载量：0

DOI	10.12208/j.ijcr.20220499
刊名	国际临床研究杂志 International Journal of Clinical Research
年，卷(期)	2022, 6(10)
作者	熊婷*,周迎,
作者单位	长沙医学院湖南长沙 ;
摘要	探讨FDI-6调控叉头框转录因子 M1( FoxM1) 对人肝癌细胞增殖、侵袭的影响。方法应用定量聚合酶链反应检测肝癌细胞HepG2中加入FDI-6后FoxM1的表达影响，细胞增殖实验和细胞迁移实验检测FoxM1下调空肝癌细胞的增殖和侵袭能力。结果在HepG2 细胞中，FDI-6≥20μmol/L可明显下调FoxM1的表达。表达。结论 FDI-6能下调 FoxM1的表达，抑制肝癌细胞增殖，导致细胞周期发生停滞，降低细胞迁移能力。
Abstract	Objective: To investigate the effects of FDI-6 regulating forkhead box transcription factor M1 (FoxM1) on the proliferation and invasion of human hepatoma cells. Methods: Quantitative polymerase chain reaction was used to detect the expression of FoxM1 in HepG2 cells after adding FDI-6. Cell proliferation and migration tests were used to detect the ability of FoxM1 to down regulate the proliferation and invasion of empty hepatoma cells. Results: In HepG2 cells, FDI-6 ≥ 20 μ Mol/L could significantly down regulate the expression of FoxM1. expression. Conclusion: FDI-6 can down regulate the expression of FoxM1, inhibit the proliferation of hepatoma cells, lead to cell cycle arrest, and reduce the ability of cell migration.
关键词	肝癌细胞；FDI-6；FoxM1；细胞增殖
KeyWord	Hepatoma cells; FDI-6; FoxM1; cell proliferation
基金项目
页码	160-162

参考文献
相关文献

[1] Shi J Y, Xing Q, Meng D, et al. Inferring the progression of multifocal liver cancer from spatial and temporal genomic heterogeneity
[J]. Oncotarget. 2016, 7(3): 2867- 2877.

[2] Chino F, Stephens SJ, Choi SS. The role of external beam radiotherapy in the treatment of hepatocellular cancer, Cancer. 2018.

[3] Lu X F, Zeng, Liang W Q, et al. FoxM1 is a promising candidate target in the treatment of breast cancer
[J]. Oncotarget. 2018, 9(1): 842-852.

[4] Yu M, Tang Z, Meng F, et al. Elevated expression of FoxM1 promotes the tumor cell proliferation in hepatocellular carcinoma
[J]. Tumor Biology, 2016(1):1-9.

[5] Weiler S M E, Pinna F, Wolf T, et al. Induction of Chromosome Instability by Activation of Yes Associated Protein and Forkhead box M1 in Liver Cancer
[J]. Gastroenterology, 2017, 152(8): 2037-2051.

[6] Bi Z, Liu W, Ding R, et al. A novel peptide, 9R-P201, strongly inhibits the viability, proliferation and migration of liver cancer HepG2 cells and induces apoptosis by down-regulation of FoxM1 expression
[J]. European Journal of Pharmacology. 2017, 796: 175-189.

[7] Gormally M V, Dexheimer T S, Marsico G, et al. Suppression of the FoxM1 transcriptional program via novel small molecule inhibition
[J]. Nature Communi- cations. 2014, 5(5):5165.

引用本文

熊婷*,周迎. FDI-6下调FoxM1抑制人肝癌细胞增殖迁移 [J]. 国际临床研究杂志. 2022; 6; (10). 160 - 162.

文献评论

相关学者

相关机构