International Journal of Internal Medicine

Objective To investigate the effect of nifedipine combined with enalapril in the treatment of elderly patients with coronary heart disease complicated with hypertension. Methods This study was carried out in the form of controlled trial in our hospital. A total of 94 elderly patients with coronary heart disease complicated with hypertension admitted to the Department of Cardiovascular Medicine from October 2020 to October 2021 were selected as the subjects and divided into control group (n=47) and observation group (n=47) by random altercountry method. The control group was treated with nifedipine alone, while the observation group was treated with nifedipine combined with enalapril. The clinical treatment effect of the two groups was evaluated. Results Compared with before treatment, the blood pressure level and cardiac function indexes, serum LP-PLA2 and HCY indexes of the two groups were decreased, and the observation group were lower than those of the control group (P < 0.05). The incidence of adverse reactions in the observation group was lower than that in the control group (P < 0.05). Conclusion The combination of nifedipine and enalapril in the treatment of elderly patients with coronary heart disease complicated with hypertension has better efficacy, and has obvious improvement effect on blood pressure, cardiac function and serum indexes, and has less adverse reactions and higher treatment safety. It should be strengthened in clinical application.

Elderly patients; Coronary heart disease (CHD).High blood pressure.Nifedipine; enalaprilat