International Journal of Internal Medicine

Objective To study the effect of DN regimen combined with three-dimensional conformal radiotherapy (3D-CRT) on tumor markers in patients with advanced esophageal cancer (EC). Methods 62 patients with intermediate and late EC in our hospital (October 2019~January 2021) were selected and divided into control group (31 cases) and observation group (31 cases) according to different treatment schemes. The control group was treated with 3D-CRT, and the observation group was treated with DN regimen combined with 3D-CRT. The clinical efficacy, swallowing function grading method score (Stooler score), European Organization for Research and Treatment of Cancer Quality of Life Scale score (EORTCQLQ-C30 score), esophageal cancer patients supplement scale score (QLQ-OESl8 score) and side effects were compared between the two groups. Results The total effective rate of the observation group was 70.97% higher than that of the control group 41.94% (P<0.05); After treatment, Stooler score and QLQ-OESl8 score in the observation group were lower than those in the control group, and EORTC QLQ-C30 score was higher than that in the control group (P<0.05); There was no significant difference in the incidence of side effects between the two groups (P>0.05). Conclusion DN regimen combined with 3D-CRT is effective in the treatment of patients with advanced EC, which can effectively reduce the level of body tumor markers, improve the swallowing function and quality of life of patients, and further alleviate their clinical symptoms.

DN scheme; 3D-CRT; esophageal cancer