International Journal of Clinical Research

Objective: To explore the value of applying print cytology (TIC) combined with rapid immunohistochemistry (RIHC) detection in the sentinel lymph node biopsy of breast cancer. Methods Patients undergoing sentinel lymph node biopsy for breast cancer were selected for the study. A total of 114 patients were admitted from July 2020 to April 2022. The hospital carried out intraoperative single and combined tests of TIC and RIHC, and performed postoperative paraffin section testing. The sensitivity, specificity, accuracy, positive predictive value, and negative predictive value of a single test and a combined test were analyzed by using the test results of postoperative paraffin sections as the gold standard. Results After postoperative paraffin sections, 57 patients developed sentinel lymph node metastasis, with a 50% positive rate. Thirty-eight cases were positive by TIC, 39 cases were positive by RIHC, and 56 cases were positive by combination test. The sensitivity of combination test and accuracy was higher than that of single test (P <0.05). Conclusion The combination of TIC and RIHC in the sentinel lymph node biopsy of breast cancer is remarkable, and the disease diagnosis rate and diagnostic accuracy is better than a single test.

TIC; RIHC; breast cancer; sentinel lymph node biopsy; diagnostic effect