International Journal of Clinical Research

Objectives To analyze the effect of large-dose omeprazole in the treatment of elderly patients with gastric ulcer and bleeding. Methods: the 100 subjects enrolled in the study were all elderly patients with gastric ulcer and bleeding who were admitted and diagnosed in the Department of Gastroenterology of our hospital from January 2019 to January 2020. They were divided into groups according to the dosage of omeprazole used during the treatment period. 50 cases of routine dose treatment were assigned to the control group, and 50 cases of high-dose treatment were assigned to the observation group. The related indexes of the two groups were compared and analyzed. Results: the total effective rate of the observation group was higher than that of the control group, the time for disappearance of main symptoms (such as hematemesis) was shorter than that of the control group, and the recurrence rate within one month was lower than that of the control group. There were differences in the comparison results of the above indicators between the groups (P < 0.05). There was no difference in the incidence of adverse reactions between groups (P > 0.05). Conclusion: high dose omeprazole is effective in treating senile gastric ulcer with bleeding.

large dose; Omeprazole; Elderly patients; gastric ulcer; Gastrorrhagia