研究项目
主持两项国家自然科学基金项目
1. SRF在缺氧诱导的肺血管重构中的作用及其机制研究(81300041)；
2. LncRNA XLOC_010588调控ctgf介导的缺氧性肺动脉高压自噬的机制(81970051)。
发表文章
1. Wang R(第一作者), Xu YJ, Liu XS, Zeng DX, and Xiang M, Knockdown of connective tissue growth factor by plasmid-based short hairpin RNA prevented pulmonary vascular remodeling in cigarette smoke-exposed rats. Archives of Biochemistry and Biophysics, 2011. 508(1): 93-100. (IF: 3.9, Q1)
2. Wang R(第一作者), Xu YJ, Liu XS, Zeng DX and Xiang M. CCN2 promotes cigarette smoke-induced proliferation of rat pulmonary artery smooth muscle cells through upregulating cyclin D1 expression. J Cell Biochem. 2012; 113(1):349-359. （IF: 4, Q2）
3. Chen C, Wang R（共同第一作者）, Zhou S, Zhao J and Xu Y. Effects of Mitochondrial ATP-Sensitive Potassium Channels on the Proliferation and Secretion of Human Airway Smooth Muscle Cells. Iranian journal of allergy, asthma, and immunology. 2014; 13(6):420-427.（IF: 1.5, Q4）
4. Wang R(第一作者), Zhou SJ, Zeng DX, Xu R, Fei LM, Zhu QQ, Zhang Y and Sun GY. Plasmid-based short hairpin RNA against connective tissue growth factor attenuated monocrotaline-induced pulmonary vascular remodeling in rats. Gene Ther. 2014; 21(11):931-937.（IF:5.1, Q1）
5. Wang R(第一作者), Li M, Zhou S, Zeng D, Xu X, Xu R and Sun G. Effect of a single nucleotide polymorphism in miR-146a on COX-2 protein expression and lung function in smokers with chronic obstructive pulmonary disease. Int J Chron Obstruct Pulmon Dis. 2015; 10:463-473. (IF: 2.8, Q3)
6. Wang R(第一作者), Yang XC, Zhou SJ and Sun GY. Anti-neutrophil cytoplasmic antibody-negative microscopic polyangiitis: A case report and literature review. Experimental and therapeutic medicine. 2015; 10(2):749-752.（IF: 2.7, Q3）
7. Zhou S, Li M, Zeng D, Sun G, Zhou J and Wang R（通讯作者）. Effects of basic fibroblast growth factor and cyclin D1 on cigarette smoke-induced pulmonary vascular remodeling in rats. Experimental and therapeutic medicine. 2015; 9(1):33-38. （IF: 2.7, Q3）
8. Zhou SJ, Li M, Zeng DX, Zhu ZM, Hu XW, Li YH, Wang R（通讯作者） and Sun GY. Expression variations of connective tissue growth factor in pulmonary arteries from smokers with and without chronic obstructive pulmonary disease. Scientific reports. 2015; 5:8564.（IF: 4.6,Q2）
9. Zhou SJ ZJ, Liu SP, Wang R（通讯作者）, Wang ZX. Arsenical keratosis caused by medication: a case report and literature. Int J Clin Exp Med. 2015; 8(1):1487-1490. IF: ESCI
10. Ding X, Zhou S, Li M, Cao C, Wu P, Sun L, Fei G, and Wang R （通讯作者）, Upregulation of SRF Is Associated With Hypoxic Pulmonary Hypertension by Promoting Viability of Smooth Muscle Cells via Increasing Expression of Bcl-2. Journal of Cellular Biochemistry, 2017. 118(9): 2731-2738. （IF: 4, Q2）
11. Zhou S, Sun L, Cao C, Wu P, Li M, Sun G, Fei G, Ding X, and Wang R（通讯作者）, Hypoxia-induced microRNA-26b inhibition contributes to hypoxic pulmonary hypertension via CTGF. Journal of Cellular Biochemistry, 2018. 119(2): 1942-1952. （IF: 4, Q2）
12. Zhou S, Liu Y, Li M, Wu P, Sun G, Fei G, Xu X, Zhou X, Zhou L, and Wang R（通讯作者）, Combined Effects of PVT1 and MiR-146a Single Nucleotide Polymorphism on the Lung Function of Smokers with Chronic Obstructive Pulmonary Disease. International Journal Of Biological Sciences, 2018. 14(10): 1153-1162.（IF:9.2, Q1）
13. Wang R (第一作者), Zhou S, Wu P, Li M, Ding X, Sun L, Xu X, Zhou X, Zhou L, Cao C, and Fei G, Identifying Involvement of H19-miR-675-3p-IGF1R and H19-miR-200a-PDCD4 in Treating Pulmonary Hypertension with Melatonin. Molecular Therapy - Nucleic Acids, 2018. 13: 44-54.（IF: 8.8, Q1）
14. Ding X, Sun G, Fei G, Zhou X, Zhou L, Wang R（通讯作者）, Pulmonary actinomycosis diagnosed by transbronchoscopic lung biopsy: A case report and literature review. Exp Ther Med, 2018. 16(3): 2554-2558. （IF: 2.7, Q3）
15. Liu Y, Zhou S, Du Y, Sun L, Jiang H, Zhang B, Sun G, and Wang R（通讯作者）， Efficacy and safety of programmed death 1 inhibitors in patients with advanced non-small cell lung cancer: a meta-analysis. Cancer Manag Res, 2019. 11: 4619-4630. （IF: 3.3, Q3）
16. Zhou S, Jiang H, Li M, Wu P, Sun L, Liu Y, Zhu K, Zhang B, Sun G, Cao C, and Wang R（通讯作者）， Circular RNA hsa_circ_0016070 Is Associated with Pulmonary Arterial Hypertension by Promoting PASMC Proliferation. Mol Ther Nucleic Acids, 2019. 18: 275-284. (IF: 8.8,Q1)
17. Zhou S, Zhu K, Du Y, Jiang H, Li M, Wu P, Xu A, Ding X, Sun L, Cao C, Sun G, and Wang R（通讯作者）， Estrogen administration reduces the risk of pulmonary arterial hypertension by modulating the miR-133a signaling pathways in rats. Gene Therapy, 2020. 27(3-4): 113-126. (IF: 5.1,Q1)
18. Zhang B, Liu Y, Zhou S, Jiang H, Zhu K, and Wang R（通讯作者）， Predictive effect of PD-L1 expression for immune checkpoint inhibitor (PD-1/PD-L1 inhibitors) treatment for non-small cell lung cancer: A meta-analysis. Int Immunopharmacol, 2020. 80: 106214. (IF: 5.6, Q1)
19. Zhu K, Zhou S, Xu A, Sun L, Li M, Jiang H, Zhang B, Zeng D, Fei G, and Wang R（通讯作者）， Microbiota Imbalance Contributes to COPD Deterioration by Enhancing IL-17a Production via miR-122 and miR-30a. Molecular Therapy - Nucleic Acids, 2020. 22(1): 520-529. (IF: 8.8, Q1)
20. Zhu K, Xu A, Xia W, Li P, Zhang B, Jiang H, Zhou S, and Wang R（通讯作者） Association Between NAT2 Polymorphism and Lung Cancer Risk: A Systematic Review and Meta-Analysis. Front Oncol, 2021. 11（1）: 567762-567770. (IF: 4.7, Q2)
21. Zhu, K., A. Xu, W. Xia, P. Li, R. Han, E. Wang, S. Zhou, and Wang R（通讯作者）, Integrated analysis of the molecular mechanisms in idiopathic pulmonary fibrosis. Int J Med Sci, 2021. 18(15): p. 3412-3424. (IF: 3.6, Q2)
22. Zhang, B., A. Xu, D. Wu, W. Xia, P. Li, E. Wang, R. Han, P. Sun, S. Zhou, and Wang R（通讯作者）, ARL14 as a Prognostic Biomarker in Non-Small Cell Lung Cancer. Journal of Inflammation Research, 2021. 14(1): p. 6557-6574. (IF: 4.5, Q2)
23. Sun, L., A. Xu, M. Li, X. Xia, P. Li, R. Han, G. Fei, S. Zhou, and Wang R（通讯作者）, Effect of Methylation Status of lncRNA-MALAT1 and MicroRNA-146a on Pulmonary Function and Expression Level of COX2 in Patients With Chronic Obstructive Pulmonary Disease. Front Cell Dev Biol, 2021. 9(1): p. 667624.( IF: 5.5, Q1)
24. Sun, L., P. Li, B. Pang, P. Wu, and Wang R（通讯作者）, Gestational Psittacosis With Secondary Hemophagocytic Syndrome: A Case Report and Literature Review. Front Med (Lausanne), 2021. 8. (IF: 3.9, Q2)
25. Liu, Y., H.M. Li, and Wang R（通讯作者）, Effectiveness and Safety of Adding Bevacizumab to Platinum-Based Chemotherapy as First-Line Treatment for Advanced Non-Small-Cell Lung Cancer: A Meta-Analysis. Front Med (Lausanne), 2021. 8: p. 616380. (IF: 3.9, Q2)
26. Jiang H, Xu A, Xia W, Xia X, Li P, Zhang B, Zhu K, Zhou S, and Wang R（通讯作者）, Nivolumab monotherapy or combination therapy with ipilimumab for lung cancer: a systemic review and meta-analysis. Cancer Cell Int, 2021. 21(1): p. 426-437. (IF: 5.8, Q1)
27. Jiang H, Xu A, Li M, Han R, Wang E, Wu D, Fei G, Zhou S, and Wang R（通讯作者）, Seven autophagy-related lncRNAs are associated with the tumor immune microenvironment in predicting survival risk of nonsmall cell lung cancer. Brief Funct Genomics, 2022. 21(3): 177-187. (IF: 4, Q2)
28. Han R, Guan Y, Li M, Xu A, Wu D, Li P, Wang E, Sun P, Fei G, Zhou S, Wang R（通讯作者）, Efficacy and Safety of Nanoadministration in the Treatment of Non-Small-Cell Lung Cancer Is Good to Some Extent: A Systematic Review and Meta-Analysis. J Oncol, 2022. 11(1): 1-11. (剔除SCI)
29. Cao C, Qiu F, Lou C, Fang L, Liu F, Zhong J, Sun W, Ding W, Yu X, Xu Q, Wang R（通讯作者）, Ruan L, and Song Q, Safety of inactivated SARS-CoV-2 vaccines in patients with allergic diseases. Respiratory Research, 2022. 23(1): 133-140. (IF: 5.8, Q1)
30. Lv D, Wang R（共同第一作者）, Chen M, Li Y, Cao C. Fish Intake, Dietary Polyunsaturated Fatty Acids, and Lung Cancer: Systematic Review and Dose-Response Meta-Analysis of 1.7 Million Men and Women. Nutr Cancer. 2022;74(6):1976-1985. (IF: 2.9, Q3)
31. Li P, Guan Y, Zhou S, Wang E, Sun P, Fei G, Zeng D, and Wang R（通讯作者）, Mortality and risk factors for COVID-19 in hemodialysis patients: A systematic review and meta-analysis. Science progress, 2022. 105(3): 003685042211108. （IF: 2.1, Q3）
32. Pulin Li, Xiaojuan Chen, Sijing Zhou, Xingyuan Xia, Enze Wang, Rui Han, Daxiong Zeng, Guanghe Fei, Wang R（通讯作者）. High Expression of DEPDC1B Predicts Poor Prognosis in Lung Adenocarcinoma. Journal of Inflammation Research, 2022.15(1):4171-4184. （IF: 4.5, Q2）
33.Wang E, Wang Y, Zhou S, Xia X, Han R, Fei G, Zeng D, Wang R（通讯作者）. Identification of three hub genes related to the prognosis of idiopathic pulmonary fibrosis using bioinformatics analysis. Int J Med Sci. 2022 Aug 15; 19(9): 1417-1429. (IF: 3.6, Q2)
34. Liu Y, Zhang W, Zhang M, Wang Y, Ma X, Jiang J, Wang R（通讯作者）, and Zeng D, DNA-PKcs participated in hypoxic pulmonary hypertension. Respiratory Research, 2022. 23(1). (IF:5.8, Q1)
35. Sun P, Xu H, Zhu K, Li M, Han R, Shen J, Xia X, Chen X, Fei G, Zhou S, Wang R（通讯作者）. The cuproptosis related genes signature predicts the prognosis and correlates with the immune status of clear cell renal cell carcinoma. Front Genet. 2022 Dec 1;13:1061382. (IF:3.7, Q2)
36. Xia X, Huang L, Zhou S, Han R, Li P, Wang E, Xia W, Fei G, Zeng D, Wang R（通讯作者）. Hypoxia-induced long non-coding RNA plasmacytoma variant translocation 1 upregulation aggravates pulmonary arterial smooth muscle cell proliferation by regulating autophagy via miR-186/Srf/Ctgf and miR-26b/Ctgf signaling pathways. Int J Cardiol. 2023 Jan 1;370:368-377. (IF:3.5, Q2)
37. Wang C, Liu Y, Zhang W, Huang Ja, Jiang J, Wang R（通讯作者）, and Zeng D, circ-BPTF serves as a miR-486-5p sponge to regulate CEMIP and promotes hypoxic pulmonary arterial smooth muscle cell proliferation in COPD. Acta Biochimica Et Biophysica Sinica, 2022. 55(3): 438-448. (IF:3.7, Q2)
38. Wang E, Zhou S, Zeng D, Wang R（通讯作者）. Molecular regulation and therapeutic implications of cell death in pulmonary hypertension. Cell Death Discov. 2023 Jul 12;9(1):239. (IF:7, Q2)
39. Han R, Huang L, Zhou S, Shen J, Li P, Li M, Wu X, Wang R（通讯作者）. Novel clinical radiomic nomogram method for differentiating malignant from non-malignant pleural effusions. Heliyon. 2023 Jul 13;9(7):e18056. (IF:4, Q2)
40. Rui Han, Youhong Guan, Min Tang, Min Li, Binbin Zhang , Guanghe Fei , Sijing Zhou , Wang R（通讯作者）. High Expression of PSRC1 Predicts Poor Prognosis in Lung Adenocarcinoma. J Cancer.2023 Oct 7;14(17):3321-3334.(IF:3.3, Q2)
41. Xingyuan Xia, Ling Huang, Sijing Zhou, Rui Han, Pulin Li, Enze Wang, Wanli Xia, Guanghe Fei, Daxiong Zeng, Wang R（通讯作者）. Hypoxia-induced long non-coding RNA plasmacytoma variant translocation 1 upregulation aggravates pulmonary arterial smooth muscle cell proliferation by regulating autophagy via miR-186/Srf/Ctgf and miR-26b/Ctgf signaling pathways. Int J Cardiol. 2023 Jan 1:370:368-377.(IF:3.2, Q2)
42. Binbin Zhang, Youhong Guan, Daxiong Zeng, Wang R（通讯作者）. Arginine methylation and respiratory disease. Transl Res. 2024 Mar 5:272:140-150.(IF:6.4,Q1)
43. Enze Wang, Binbin Zhang, Ling Huang, Pulin Li, Rui Han, Sijing Zhou, Daxiong Zeng, Wang R（通讯作者）. LncRNA MIR210HG promotes phenotype switching of pulmonary arterial smooth muscle cells through autophagy-dependent ferroptosis pathway. Apoptosis. 2024 Apr 18. Online ahead of print.(IF:6.1,Q1)
44. Pulin Li, Ling Huang, Rui Han, Min Tang, Guanghe Fei, Daxiong Zeng, Wang R（通讯作者）. Machine learning and radiomics for predicting efficacy of programmed cell death protein 1 inhibitor for small cell lung cancer: A multicenter cohort study. Clin Transl Med. 2024 Jun;14(6):e1673.(IF7.9,Q1)
45. Wenlong Wu, Sijing Zhou, Guanghe Fei, Wang R（通讯作者）. The role of long noncoding RNA MEG3 in fibrosis diseases. Postgrad Med J. 2024 Mar 1:qgad124. Online ahead of print.(IF:3.6，Q1)
46. Pulin Li, Ling Huang, Rui Han, Min Tang, Guanghe Fei, Daxiong Zeng, Wang R（通讯作者）. Safety and efficacy of Paxlovid in the treatment of adults with mild to moderate COVID-19 during the omicron epidemic: a multicentre study from China. Expert Rev Anti Infect Ther. 2024 Jun;22 (6):46 9-47 7. (IF:4.2, Q1)
47. Min Tang , Yue Wang , Pulin Li , Rui Han , Ran Wang（通讯作者） . Assessing the benefits and safety profile of incorporating poly ADP-ribose polymerase (PARP) inhibitors in the treatment of advanced lung cancer: a thorough systematic review and meta-analysis. Front Pharmacol. 2024 Jun 21:15:1338442. (IF:4.4, Q1)