代谢型谷氨酸受体3基因多态性与中国北方汉族男性酒依赖关系的研究-国际精神病学杂志-CSCIED科技核心评价数据库-手机版

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代谢型谷氨酸受体3基因多态性与中国北方汉族男性酒依赖关系的研究

An association study of polymorphic GRM3 gen with alcohol dependence in northern Han Chinese men.

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刊名	国际精神病学杂志 Journal of International Psychiatry
年，卷(期)	2016, 43(1)
作者	夏炎*,胡建, 唐春玲, 夏炎,
作者单位	哈尔滨医科大学附属第一医院 ;
摘要	探讨中国北方汉族人群代谢型谷氣酸受体3 (GRM3) 基因多态性与酒依赖的相关性。方法采用聚合略健反应(PCR)和连接略检测反应(LDR)方法,检测248例酒依赖患者和235例对照组的 GRM3组基因上10个位点的单核寄酸多态性。结果酒依赖组与对照组相比较, rs6465084位点的 A等位基因和 A/A基因型频率明显增高(P<0. 05) 。单体型 TAATATT、CAGTATT、 TCGTATT、 CAATAGC、 TAATATC频率在酒依赖组和对照组中具有统计学显著差异(P<0.05) ,其中单体型 TAATATT 频率较对照组明显增高(P<0.001) ,且频率≥5%。结论GRM3基因可能是酒依赖发生的候选基因之一。
Abstract	〇bjective To investigate the association of metabotropic glutamate receptor(GRM3) gene poly-morphic and alcohol dependence in a Han population in northern China. Methods 248 male alcohol - dependent patients and235 male control subjects were recruited. Ten SNPs in the GRM3 region were studied. Genotyping of SNPs was done using ligase detecLion reactions. Results The frequency of A allele of SNP rs6465084 was greater in alcohol-dependent group than in control group. Significant differences of haplotype frequencies were observed in five combinations(including TAATATT, CAGTATT, TCGTATT, CAATAGC, TAATATC) in the linkage disequilib- rium(LD) constructed by seven SNPs between the groups. The frequency of TAATATT haplotype was greater in alcoholic group than in control group, and higher than5%. Conclusion GRM3 gene may be as a risk factor of alcohol dependence.
关键词	代谢型谷氣酸受体3;单核寄酸多态性;酒依赖
KeyWord	Metabotropic glutamate receptor3; Single nucleotide polymorphism; Alcoho1 dependence
基金项目
页码	34-36

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夏炎*,胡建, 唐春玲, 夏炎. 代谢型谷氨酸受体3基因多态性与中国北方汉族男性酒依赖关系的研究 [J]. 国际精神病学杂志. 2016; 43; (1). 34 - 36.

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