Journal of International Psychiatry

〇bjective To compare the efficacy and security of quetiapine and citalopram in the treatment ofpost-stroke depression. Method 112 patients with post-stroke depression were divided into two groups which were re- ceived quetiapine or citalopram for8 weeks respectively. And the curative effect and side reaction were evaluated with Hamilton depressive scale(HAMD), activity of Daily Living scale(ADL) and treatment emergent symptom scale(TESS) respectively before and after the treatment in2nd, 4th, 8th weekend. Results After8 weeks treat- ment, there were no significant differences in the score of HAMD and CGI-SI between two groups (P>0.05). The total effective rates of quetiapine and citalopram were71.4% and75.0% respectively, without any statistically sig- nificant difference between groups(P>0.05). Patients in quetiapine group had more drowsiness and dry mouth, yet patients in cita1opram had more nausea and vomiting. Conclusion Quetiapine has a similar efficacy with citato- pram in the treatment of the patients with post-stroke depressions, the security is higher, and the side reaction is slighter.

Quetiapine; Cita1opram; Post-stroke depression