Journal of International Psychiatry

〇bjective To investigate the influence of frontal neural biochemical substances before and aftertreatment with tandospirone for anxiety patients. Methods 90 cases according to a random number table method from January to December in2014 were recruited they were divided into two groups(45 cases for each). The obser_ vation group were treated with tandospirone, control group were used buspirone for treatment. SAS uses HAMA Anx- iety Scale and self-evaluation form after the anxiety of patients before and after treatment were assessed analysis, and proton magnetic resonance spectroscopy was used to evaluate to the level of the prefrontal cortex and hippocampus (NAA, oho and Glx value) of patients, and the treatment effect for two groups were analyzed. 45 normal cases in our hospital were compared with them. Results HAMA and SAS scores of two groups before treatment were not sig- nificantly different(P>0.05) , after treatment, HAMA and SAS scores of both groups were significantly lower than the scores before treatment, and the observation group were significantly lower than the control group(P<0.05). After treatment, NAA, oho and Glx values of observation group were higher than the control group(P<0.05) and the total effective rate of Lhe observaLion group were91. 11%, that was higher Lhan Lhe control group(80%) (P< 0.05). Conclusion Anxiety disorder has neuronal dysfunction in the frontal, tandospirone have a good effect for it, it can decrease dependence of patients and effectively relieve anxiety and mood regulation.

Tandospirone; Anxiety; Prefronta1 neura1 biochemica1 substances