Journal of International Psychiatry

Abstract】 Objective To compare the changes of serum uric acid levels in bipolar mania patients before and aftertreatment and explore its clinical significance. Methods 79 inpatient with manic episode of bipolar disorder（patient （patient patientgroup）and77healthyindividuals（controlgroup）wereenrolled.TheseveritywasassessedtheYoungsmanicscalebe- ）and77healthyindividuals（controlgroup）wereenrolled.TheseveritywasassessedtheYoungsmanicscalebe- and 77 healthy individuals（controlgroup）wereenrolled.TheseveritywasassessedtheYoungsmanicscalebe- （controlgroup）wereenrolled.TheseveritywasassessedtheYoungsmanicscalebe- control group）wereenrolled.TheseveritywasassessedtheYoungsmanicscalebe- ）wereenrolled.TheseveritywasassessedtheYoungsmanicscalebe- were enrolled. The severity was assessed the Youngs manic scale be-fore and after the treatment. The observation cycle was Eight weeks. Serum uric acid level was tested before and after thetreatment. Results Bipolar mania patients had higher serum uric acid levels ［（369.28±107.59） ［（369.28±107.59） 369.28±107.59）μmol/L］thanhealthy ］thanhealthy than healthycontrols ［（301.77±76.04） ［（301.77±76.04） 301.77±76.04）μmol/L］beforethetreatment（ ］beforethetreatment（ before the treatment（P <0.01）. Aftertreatment，theserumuricacid［（331.94± ）. Aftertreatment，theserumuricacid［（331.94± . After treatment，theserumuricacid［（331.94± ，theserumuricacid［（331.94± the serum uric acid ［（331.94± ［（331.94± 331.94±94.58）μmol/L］wassignificantlydecreased（ ］wassignificantlydecreased（ was significantly decreased（P <0.01），but still higherthanthat of healthycontrols（ ），but still higherthanthat of healthycontrols（ but still higher than that of healthy controls（P <0.01）. Cor- ）. Cor- . Cor-relation analysis showed：beforethetreatment，theserumuricacidlevel hasnothingtodowiththescoresofmaniarat- ：beforethetreatment，theserumuricacidlevel hasnothingtodowiththescoresofmaniarat- before the treatment，theserumuricacidlevel hasnothingtodowiththescoresofmaniarat- ，theserumuricacidlevel hasnothingtodowiththescoresofmaniarat- the serum uric acid level has nothing to do with the scores of mania rat-ing scale（r=0.11，P =0.37）. However，after8weekstreatments，asignificantlypositivecorrelationbetweenthese- ）. However，after8weekstreatments，asignificantlypositivecorrelationbetweenthese- . However，after8weekstreatments，asignificantlypositivecorrelationbetweenthese- ，after8weekstreatments，asignificantlypositivecorrelationbetweenthese- after 8 weeks treatments，asignificantlypositivecorrelationbetweenthese- ，asignificantlypositivecorrelationbetweenthese- a significantly positive correlation between the se-rum uric acid level with the scores of mania rating scale（r=0.28，P =0.02）. ）. Conclusions Patients with bipolar maniamay suffer from purinergic system dysfunction. The serum uric acid levels in acute phase of mania increased，whileit ，whileit while itdecreased when clinical symptoms improved.

Bipolar disorder；Mania；Uricacid