Journal of International Psychiatry

Objective To explore the effect and safety of olanzapine in the child and adolescent patients withfirst-episode schizophrenia. Methods 80 child and adolescent patients with first-episode schizophrenia were selectedand randomly divided into the study group（n =40）andthecontrolgroup（ ）andthecontrolgroup（ and the control group（n =40）. Thepatientsofthestudygroupwere ）. Thepatientsofthestudygroupwere . The patients of the study group weregiven olanzapine and the patients of the control group were given risperidone. The treatment effect of the 2 groups werecompared. Using positive and negative symptoms scale（PANSS）andadverseevent scale（TESS）beforetreatment and （PANSS）andadverseevent scale（TESS）beforetreatment and PANSS）andadverseevent scale（TESS）beforetreatment and ）andadverseevent scale（TESS）beforetreatment and and adverse event scale（TESS）beforetreatment and （TESS）beforetreatment and TESS）beforetreatment and ）beforetreatment and before treatment andafter treatment in patients with two groups of 1，2，6，8weeksof assess. ，2，6，8weeksof assess. 2，6，8weeksof assess. ，6，8weeksof assess. 6，8weeksof assess. ，8weeksof assess. 8 weeks of assess. Results Study group and control group totaleffective rate with no statistically significant difference（P >0.05），1，2weeksaftertreatment，studygroupof pa- ），1，2weeksaftertreatment，studygroupof pa- 1，2weeksaftertreatment，studygroupof pa- ，2weeksaftertreatment，studygroupof pa- 2 weeks after treatment，studygroupof pa- ，studygroupof pa- study group of pa-tients with total scores of PANSS score was significantly lower than control group（P <0.05），thecontrol grouppatients ），thecontrol grouppatients the control group patientsakathisia and tremor had a significantly higher incidence of adverse reactions observed group（P <0.05），therestofthe ），therestofthe the rest of theadverse reactions has no statistically significant difference between the two groups. Children with weight of the addedvalue is significantly higher than control group（P <0.05）. ）. Conclusion Olanzapine is a kind of effective fast，curative ，curative curativeeffect is distinct，thetreatment of childandadolescent schizophreniadrug，but olanzapinecanincreasetheweight of ，thetreatment of childandadolescent schizophreniadrug，but olanzapinecanincreasetheweight of the treatment of child and adolescent schizophrenia drug，but olanzapinecanincreasetheweight of ，but olanzapinecanincreasetheweight of but olanzapine can increase the weight ofthe patients，forapplicationinchildandadolescentpatientswithschizophrenianeedcarefulconsideration. ，forapplicationinchildandadolescentpatientswithschizophrenianeedcarefulconsideration. for application in child and adolescent patients with schizophrenia need careful consideration.

Olanzapine；Risperidone；Child and adolescent；Schizophrenia