齐拉西酮对精神分裂症患者执行功能、述情障碍的远期影响
Long-term influences of ziprasidone on executive functions and alexithymia of patients with schizophrenia
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| DOI |
| 刊名 |
Journal of International Psychiatry
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| 年，卷(期) |
2016, 43(3) |
| 作者 |
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| 作者单位 |
河南省信阳市精神病医院 ;
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| 摘要 |
目的 讨论齐拉西酮精神分裂症患者执行功能、述情障碍的远期影响。方法 对精神分裂症患者按照随机分组原则，研究组36例以齐拉西酮治疗，对照组以氯氮平治疗，好转后以相对稳定剂量维持；随访两年，以威斯康星卡片测验（WCST）评估执行功能。以述情障碍量表（TAS-20）评定定述情碍障碍。结果 2年研究组的完成分类数、正确应答数，概念化水平百分数显著高于对照组差异有统计学意义（P <0.01）。错误应答数、非持续性错误数、完成第一次分数类应答应数显著低于对照组差异有统计学意义（P <0.01），研究组述情障碍各因子分均显著低于对照，组差异有统计学意义（P <0.05）。结论 齐拉西酮能较好的改善精神分裂症患者的执行功能和述情障碍。
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| Abstract |
Objecctive To explore long-term influences of ziprasidone on executive functions and alexithymiaof patients with schizophrenia. Methods By randomly grouped，36 cases schizophrenia were treatad with ziprasidoneas the study group and 33 cases treated with clozepine as the control one.They were maintained with relative stable drugdosage after ill-condition improving.Wisconsin Card Sorting Test（WCST）were used to evaluate and compare the twogroup executive，The twenty-item Toronto Alexithymia Scale（TAS-20）were used to evaluate theparticipants alexi-thymia. Results While the number of correct classification，number of correct response，the percentage of correctresponse and response rate of score conceptualization was significantly higher in ziprasidone group（P <0.01）and num-ber of wrong response，non-preservative errors and failing to keep fixe posture was significantly lower in ziprasidonesgroup（P <0.01）.Factor scores of TAS-20 were were significantly lower in ziprasidones group than clozapines group（P <0.05）. Conclusion Ziprasidone shows better long-trem efficaccy in improving executive function and diminish-ing Alexithymia.
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| 关键词 |
齐拉西酮；精神分裂症；执行功能；述情障碍
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| KeyWord |
Schizophrenia；Ziprasidone Executive function；Alexithymia
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| 基金项目 |
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| 页码 |
396-398 |
李新峰*.
齐拉西酮对精神分裂症患者执行功能、述情障碍的远期影响 [J].
国际精神病学杂志.
2016; 43; (3).
396 - 398.