Journal of International Psychiatry

Objective　To investigate the clinical effects and safety of quetiapine combined with conventionalanti-anxiety drugs on patients with generalized anxiety disorder（ GAD）whose symptoms under poor control. Methods　From January 2014 to December 2014，130 GAD patients with symptoms for poor control were chosen in our hospitaland randomly divided into control group and treatment group，65 cases in each group. Patients in control group weregiven routine anti-anxiety drug therapy，while the patients in treatment group were treated with quetiapine on the basisof the control group. Clinical effects，HAMA scores，TAS scores and PSQI scores before and after treatment andthe adverse reaction incidence of both groups were compared. Results　The clinical effect of treatment group was significantlybetter than the control group，the difference was statistically significant（ χ2=9.75，P<0.05）. The HAMAscores，TAS scores and PSQI scores in 2，4 and 8 weeks after treatment of the treatment group was significantly betterthan control group，the difference was statistically significant（P<0.05）. The incidence of dizziness in the treatmentgroup was significantly higher than that in the control group，the difference was statistically significant（χ2=8.71，P<0.05）. There was no significant difference between the two groups in the incidence of insomnia，constipation andloss of appetite（χ2=2.14，1.33，3.40，P>0.05）. Conclusion　Quetiapine assisted with conventional anti-anxietyscheme in the treatment of GAD patients with symptoms for poor control possess the advantages including improvinganxiety symptoms，reducing the alexithymia degree and enhancing the quality of sleep but it may increase the risk ofadverse effects.

Quetiapine； GAD；Clinical Effects；Safety