Journal of International Psychiatry

Objective　To explore the effectiveness of aripiprazole and cognitive behavioral intervention therapycombinational therapy on the cognitive function of schizophrenia. Method　86 schizophrenia were randomly dividedinto the control group and the treatment group. The control group took orally with aripiprazole and the treatment groupwas treated with aripiprazole and cognitive behavioral intervention therapy combination. Postive and negtive symptomsscale（PANSS），Wisconsin card sorting test （WSCT），and China revised wechsler memory scale （WMS-RC）wereused to assess the mental status and cognitive function of the patients at 3 and 6 months，resceptively after treatment.Results　（1）Mental symptoms evalution：in the control group ，as compared with pre-treatment，there was signifi-cant difference after 3 months’ treatment （P <0.05），and as compared with 3 months’ treatment，there was significantdifference after 6 months’ treatment （P <0.05）.In the treatment group，as compared with 3 months’ treatment，therewas significant difference after 6 months’ treatment （P <0.05）. However，in the same treatment time point，there wasno significant difference between the two groups （P >0.05）.（2）Cognitive function assessment：In the control group，as compared with pre-treatment，there was no significant difference after 3 months’ treatment （P >0.05）. And ascompared with 3 months’ treatment，there was significant difference after 6 months’ treatment （P <0.05）.There wassignificant difference in the same treatment time point （P <0.05）, in the treatment group，as compared with 3 months’treatment，there was significant difference after 6 months’ treatment （P <0.05）. Conclusion　As compared with tak-ing aripiprazole medicine alone，aripiprazole and cognitive behavioral intervention therapy can better improve the cog-nitive function of the schizophrenia patients，but has no marked advantage in the promotion of their symptoms.

Aripiprazole；Cognitive behavioral intervention；Schizophrenia