Journal of International Psychiatry

Objective　To investigate the clinical efficacy of risperidone combined with small dose of lithium carbonatein the treatment of elderly patients with chronic schizophrenia. Methods　80 patients with chronic schizophreniawere divided into the control group and the experimental group. The control groups were treated with risperidone, and theexperimental group with risperidone combined with small dose of lithium carbonate, the efficacy of the two groups wereobserved. Results　3 months after treatment，the scale scores of BPRS in the experimental group were slightly lowerthan that of the control group（P>0.05），6 months after treatment，the scores of BPRS，BPRS-ACTV（activated），BPRS-ANDP（anxiety and depression）, compared before treatment, were statistically significant（P<0.05），the controlgroup slightly improved，but compared with before treatment，had no statistical significance（P>0.05），6 monthsand 12 months after treatment，the experimental group were lower than those of the control group（P<0.05）；and 12months after treatment，two groups of SANS score，BPRS-HOST（hostile）factor score compared with before treatmentwere improved，and the experiment group improved more significantly（P<0.05），in the numerical，experimentalgroup were significantly lower than the control group（P<0.05）；In effect，the experimental group was better than thecontrol group，the adverse reaction was significantly lower than the control group（P<0.05）. Conclusion　Using risperidonecombined with lithium carbonate therapy can significantly improve the symptoms of the elderly paitients withchronic schizophrenia, and the safety is relatively high，it is worth promoting.

Risperidone；Senile chronic schizophrenia；Low dose lithium carbonate；Curative effect