| Abstract |
Methods: 80 cases of cerebral infarction patients with cognitive impairment and depression in our hospital from January 2015 to June 2016 were selected.The patients were divided into fluoxetine group (n=40) and combination group (n=40) according to different treatment methods. Fluoxetine group was given fluoxetine treatment, the combination group was given Ai Sciplan treatment on the basis of fluoxetine group, the two groups were treated for 8 weeks.The Hamilton Depression Scale (Hamilton depression scale, HAMD) was used to evaluate the degree of depression before and after treatment for 1 weeks, 4 weeks and 8 weeks after treatment.The Montreal cognitive assessment scale (Montreal Cognitive, Mo CA) and Barthel index (index), Assessment (Barthel, BI) were used to evaluate the recovery of cognitive function and daily living ability of the two groups before and after treatment.The effective rate of the two groups was compared, and the adverse reactions of the two groups were observed. Results: Two groups of patients before treatment HAMD score compared to no significant difference (P > 0.05), but after 1 weeks of treatment, 4 weeks and 8 weeks after the combined group HAMD were compared with fluoxetine group decreased (P<0.05)Two groups of patients after treatment of Mo CA and BI scores were higher than before treatment, and the combination of Mo and BI in CA group was significantly better than that of fluoxetine group (P<0.05)The effective rate of combined treatment group was 92.50% (37/40) was significantly higher than the effective rate of fluoxetine treatment group 75% (30/40) (P< 0.05)The adverse reactions in the combination group decreased appetite in 5 cases, 3 cases of 1 cases of nausea, dry mouth, dizziness in 3 cases, 1 cases of diarrhea, 2 cases of constipation, 6 cases of adverse reactions of fluoxetine decreased appetite, nausea in 6 cases, 5 cases of constipation, 2 cases of tachycardia, adverse reactions of two groups were compared to no statistical significance (P>0.05).Conclusion: The curative effect of fluoxetine combined with Ai Sciplan therapy associated with depression in patients with cerebral infarction significantly cognitive impairment, can significantly reduce the degree of depression, improve cognitive function, improve the patients life skills, and faster, less adverse reactions, it is worthy of clinical promotion.
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