| Abstract |
【 Abstract】objective: To discuss the effect study of Donepezil joint Quetiapine in treatment of patients with of behavioral and psychological symptoms of dementia.Methods: 200 patients with dementia were selected from April 2014 to March 2017 in our Hospitals. According to different treatments, all patients were divided into observation group (100 cases)and control group(100 cases), the control group was given Donepezil(10mg/time,1time/d), the observation group on the basis were given Quetiapine(350mg/time,1time/d), two groups treatment time were 6 months.Statistical analyzed all of patients’ clinical curative effect, changes of cognitive level and life ability , adverse reactions. Results: Total effective rate of the observation group was significantly higher than the control group, there was statistically significant difference (P<0.05).Before intervention, MoCA, ADL scores of two groups had no significant difference (P>0.05). After intervention, two groups of MoCA scores were higher and ADL scores were lower, the observation group MoCA scores raise more obvious and ADL lower more obvious, there was statistically significant difference (P<0.05). The incidence of adverse reactions of two groups had no significant difference (P>0.05). Conclusions: Donepezil joint Quetiapine in treatment of patients with behavioral and psychological symptoms of dementia has more significant effect with adverse reaction, improve cognitive ability, mental symptoms and life ability, it’s worth for further clinical promotion.
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