Journal of International Psychiatry

Abstract: Objective:To investigate the effect of comprehensive rehabilitation training in combination with donepezil on rehabilitation efficacy of patients with Alzheimer type dementia (AD) and event-related potential.Method：A total of 112 cases of patients with Alzheimer’s disease（AD）from January 2015 to December 2016 were selected as the research objects, and divided into observation group and control group according to the random number table method, with 56 cases in each group. The control group was treated with donepezil hydrochloride, and the observation group was combined with rehabilitation training, After 3 months of follow-up visit, the cognitive function, living quality and event-related potential in the two groups were compared. Results: The score of Montreal cognitive assessment scale (MoCA) in observation group was significantly higher than that in control group, and the scores of fitness, energy and memory were significantly higher than those in control group (P<0.05, P<0.01); the incubation periods of endogenous potentials N2 and P3 were significantly shorter than those in control group, and the amplitude of P3 was significantly higher than that in control group (P<0.05, P<0.01).Conclusion: Comprehensive rehabilitation training in combination with donepezil can help to improve the cognitive function and living quality of AD patients, which may be related to the regulation of the event-related potential of the patients.

Keyword: Alzheimers dementia; donepezil hydrochloride; comprehensive rehabilitation training; event related potential