Journal of International Psychiatry

Affiliated Hospital of Yanan University Shanxi yanan,716000[Abstract] Objective To investigate the correlation between premature ovarian failure (POF) and anxiety and depression.Methods90 cases of patients with POF treated in our hospital during February 2014 to June 2016(observation group) and 60 healthy volunteers who were examined in our hospital during the same period (the healthy group) were selected as the subjects. The anxiety and depression symptoms in the two groups were evaluated with the Hospital Anxiety and Depression Scale(HADS), and changes of serum hormones [estradiol (E2), prolactin (PRL)] were determined by electrochemiluminescence method. The Connor-Davidson Resilience Scale (CD-RISC) scores were compared between the two groups, and the correlation between POF and anxiety and depression was analyzed by Sperman correlation analysis.Results The anxiety score and depression score of the observation group were higher than those of the healthy group(P< 0.05). The levels of serum E2 and PRL in patients with POF in menopausal transitional period and postmenopausal period were significantly lower than those in the child-bearing period(P< 0.05). Sperman correlation analysis showed that there was no obvious correlation between anxiety and depression scores and serum E2 and PRL levels in patients with POF (P> 0.05) butanxiety and depression were negatively correlated with resilience (P< 0.05).Conclusion POF is often associated with anxiety and depression symptoms, and the resilience of patients with POF is obviously negatively related to anxiety and depression. The diagnosis and treatment of POF shall be gradually changed from the biomedical patternto bio-social and psychological model.

[Keywords] Premature ovarian failure; Anxiety; Depression; Hormone; Correlation